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[Occult renal disease and drug prescription in primary care]
José María Peña Porta1, Meliton Blasco Oliete, Carmen Vicente de Vera Floristan
1Unidad de Nefrología, Hospital de Barbastro, Huesca, España. porta@hispavista.com
Insights
Chronic kidney disease (CKD) affects over 21% of elderly patients, with occult kidney disease (OKD) impacting 10%. Early GFR estimation in primary care can prevent adverse drug effects in this population.
Area of Science:
- Nephrology
- Geriatrics
- Primary Care Medicine
Context:
- Chronic kidney disease (CKD) and occult kidney disease (OKD) are significant health concerns in the elderly population.
- Primary care settings play a crucial role in managing chronic conditions in older adults.
Purpose:
- To determine the prevalence of CKD (defined by estimated glomerular filtration rate [eGFR] <60ml/min/1.73m(2)) and OKD (normal serum creatinine with eGFR <60) in patients over 65 years.
- To assess the prescription patterns of potentially nephrotoxic drugs in this demographic.
Summary:
- A retrospective study of 3286 elderly patients (age >65) in Spain revealed a 21.2% prevalence of CKD and 10.1% prevalence of OKD.
- A significant proportion of patients received potentially nephrotoxic medications, including NSAIDs and drugs causing hyperkalemia.
Impact:
- Highlights the high burden of kidney disease in the elderly primary care population.
- Emphasizes the importance of routine GFR estimation for preventing adverse drug events and improving patient outcomes.
Objective:
To study the prevalence of chronic kidney disease (CKD) [glomerular filtration rate (GFR) <60ml/min/1.73m(2)] and occult kidney disease (OKD) (normal serum creatinine values with GFR <60) in elderly patients.
Design:
Retrospective, observational study.
Setting:
Four primary care centres in the province of Huesca, Spain.
Participants:
About 4014 patients older than 65 years were randomly selected.
Main Measurements:
GFR was calculated for all subjects using the four-variable modified MDRD equation. We registered all drugs prescriptions to the patients during a period of twelve months focusing on the potential nephrotoxic drugs.
Results:
After exclusions, GFR was estimated in 3286 patients (1424 men of 75.49+/-6.6 years and 1862 women of 76.29+/-7.04 years; P=.001). The prevalence of CKD was 21.2%. A total of 10.1% of patients (12.8% of women and 6.44% of men) had OKD. We recorded the complete drug prescription in 269 patients. Mean of all different drugs that were prescribed by patient-year was 10.69+/-5.92 (men 9.55+/-5.57 and women 11.11+/-6; P=.05)]. A large number of patients were treated with potentially dangerous drugs, particularly the non-steroidal anti-inflammatory drugs with 165 cases (61.34%), and 72% were exposed to drugs that can lead to hyperkalaemia.
Conclusions:
We conclude that GFR estimation by clinical laboratories in the setting of primary care can contribute to prevent the adverse effects of inappropriate drug prescriptions.
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