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Application of modern NMR techniques in the structure determination of microbial transformation products from sterols
1School of Pharmacy, College of Medicine, National Taiwan University, Republic of China.
Proceedings of the National Science Council, Republic of China. Part B, Life Sciences
|April 1, 1991
Abstract:
Microbial transformations of cycloartenol, 24-methylenecycloartanol and lanosterol with Mycobacterium sp. (NRRL B-3805) resulted in the isolation and characterization of five C19 steroids. Details of the tremendous structural modifications of these metabolites from their parent compounds were clarified by 2D nmr techniques. The stereochemistry of these novel metabolites was determined by nOe studies.