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Renal Capsule Xenografting and Subcutaneous Pellet Implantation for the Evaluation of Prostate Carcinogenesis and Benign Prostatic Hyperplasia

Renal Capsule Xenografting and Subcutaneous Pellet Implantation for the Evaluation of Prostate Carcinogenesis and Benign Prostatic Hyperplasia

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Injection therapy for prostatic disease: A renaissance concept.

Arash M Saemi¹, Jeffrey B Folsom, Mark K Plante

¹Division of Urology, Department of Surgery, University of Vermont, Burlington, Vermont, USA.

Indian Journal of Urology : IJU : Journal of the Urological Society of India

|May 27, 2009

Summary

Intraprostatic injection therapy, a minimally invasive treatment for benign prostatic hyperplasia (BPH)-related lower urinary tract symptoms (LUTS), shows promise. Further research is needed before widespread clinical use.

Keywords:

Benign prostatic hyperplasia injection prostate prostatic disease

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Area of Science:

Urology
Minimally Invasive Therapies

Background:

Intraprostatic injection therapy was initially for prostatic infections but is now explored for lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH).
This minimally invasive surgical therapy (MIST) has a history spanning over a century and is experiencing renewed interest.

Purpose of the Study:

To review the historical evolution of intraprostatic injection therapy.
To examine various delivery routes (transperineal, transrectal, transurethral) and injectants used in prostatic conditions.

Main Methods:

A comprehensive literature review of intraprostatic injections was conducted.
MEDLINE database searches covered publications from 1966 to 2007, supplemented by historical documents dating back to 1832.

Main Results:

Transperineal and transurethral injection routes have undergone the most systematic patient evaluation.
Most injectants induce localized coagulative necrosis and reduce gland volume, offering varying LUTS relief.
Anhydrous ethanol (AE) is the most studied injectant.

Conclusions:

Injection therapy is a viable, minimally invasive treatment for prostatic conditions, with over a century of investigation.
Additional laboratory research and ongoing clinical trials are essential for broader clinical adoption.