Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Synthesis of a Series of Ln(III) (Ln = La, Ce, Lu) Aryl Complexes and Analysis of Their Ln-L Bonding Using Multinuclear NMR Spectroscopy and DFT Calculations.

Inorganic chemistry·2026
Same author

A novel therapeutic monoclonal antibody targeting PZR demonstrates potent anti-metastatic efficacy in triple-negative breast cancer.

Journal of translational medicine·2026
Same author

Zoledronic Acid Inhibits the Growth of ER-Positive Breast Cancer Cells by Inducing Ferroptosis.

Biomolecules & therapeutics·2026
Same author

Remote ischaemic conditioning in patients with supratentorial intracerebral haemorrhage (RICH-2): a multicentre, randomised, sham-controlled phase 3 trial in China.

EClinicalMedicine·2026
Same author

Gastrodin Alleviates Tau Hyperphosphorylation Associated with AKT/GSK-3β Signaling Changes in an Alzheimer's Disease Cell Model.

Journal of visualized experiments : JoVE·2026
Same author

The <i>Cl1978</i> gene regulates delphinidin-based anthocyanin accumulation in a rare purple Wampee (<i>Clausena lansium</i>).

Food chemistry. Molecular sciences·2026
Same journal

A cheminformatics and DFT exploration of a brominated sulfonamide with nonlinear optical response and preliminary in silico bioactivity assessment.

Molecular diversity·2026
Same journal

Triazoles as enzyme inhibitors: synthetic advances, mechanism of action, molecular docking studies and structure-activity relationships.

Molecular diversity·2026
Same journal

Synthesis of 9H-furo[2,3-f]chromenes using multicomponent reactions of euparin: investigation of biological activity.

Molecular diversity·2026
Same journal

Discovery of novel perillyl and myrtenyl nucleobase conjugates as dual anti-Alzheimer and antimicrobial agents.

Molecular diversity·2026
Same journal

Integrative network pharmacology and molecular modelling identify taxifolin as a potential modulator of melatonin receptor MT1 in mood disorders.

Molecular diversity·2026
Same journal

Design, synthesis and biological evaluations of novel VEGFR-2 inhibitors based on Fruquintinib and Cabozantinib.

Molecular diversity·2026
See all related articles

Related Experiment Video

Updated: Jun 22, 2026

Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons
08:04

Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons

Published on: June 6, 2025

Mutation patterns in human alpha-galactosidase A.

Shaomin Yan1, Guang Wu

  • 1Guangxi Academy of Sciences, 98 Daling Road, Nanning, Guangxi Province, 530007, China.

Molecular Diversity
|May 27, 2009
PubMed
Summary
This summary is machine-generated.

Unpredictable amino-acid pairs in proteins are more sensitive to mutations. This study converts protein sequences into numerical data to analyze mutation patterns, finding mutations reduce prediction errors.

More Related Videos

In Vitro Enzyme Measurement to Test Pharmacological Chaperone Responsiveness in Fabry and Pompe Disease
10:16

In Vitro Enzyme Measurement to Test Pharmacological Chaperone Responsiveness in Fabry and Pompe Disease

Published on: December 20, 2017

Saccharomyces cerevisiae Models of Alzheimer's Disease to Screen Genes, Mutations, and Chemicals Affecting Amyloid Beta Production by &#947;-Secretase
11:57

Saccharomyces cerevisiae Models of Alzheimer's Disease to Screen Genes, Mutations, and Chemicals Affecting Amyloid Beta Production by γ-Secretase

Published on: June 24, 2025

Related Experiment Videos

Last Updated: Jun 22, 2026

Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons
08:04

Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons

Published on: June 6, 2025

In Vitro Enzyme Measurement to Test Pharmacological Chaperone Responsiveness in Fabry and Pompe Disease
10:16

In Vitro Enzyme Measurement to Test Pharmacological Chaperone Responsiveness in Fabry and Pompe Disease

Published on: December 20, 2017

Saccharomyces cerevisiae Models of Alzheimer's Disease to Screen Genes, Mutations, and Chemicals Affecting Amyloid Beta Production by &#947;-Secretase
11:57

Saccharomyces cerevisiae Models of Alzheimer's Disease to Screen Genes, Mutations, and Chemicals Affecting Amyloid Beta Production by γ-Secretase

Published on: June 24, 2025

Area of Science:

  • Biochemistry
  • Bioinformatics
  • Computational Biology

Background:

  • Protein sequences, typically represented by 20 letters, lack inherent scalar or vector properties, complicating pattern analysis.
  • Studying mutation patterns necessitates a numerical domain for effective analysis.

Purpose of the Study:

  • To develop a method for analyzing protein mutation patterns by converting 20-letter sequences into scalar sequences.
  • To identify amino-acid pairs most sensitive to mutations in alpha-galactosidase A.

Main Methods:

  • Utilized amino-acid pair predictability to transform protein sequences into scalar representations.
  • Analyzed 137 mutations of alpha-galactosidase A to assess mutation sensitivity.

Main Results:

  • Demonstrated that less predictable amino-acid pairs exhibit higher sensitivity to mutations.
  • Observed a trend where mutations tend to decrease the discrepancy between predicted and actual amino-acid pair frequencies.

Conclusions:

  • Amino-acid pair predictability is a key factor in understanding protein mutation sensitivity.
  • The conversion to scalar sequences provides a viable numerical approach for studying mutation impacts on protein sequences.