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Gomisin G Inhibits Pancreatic Cancer Cell Growth by Promoting YAP Degradation

Lan Li1, Jiayu Chen2, Jiayi Shao2

  • 1School of Public Health Wenzhou Medical University Wenzhou China.

Food Science & Nutrition
|July 26, 2026
PubMed

Insights

Gomisin G, derived from Schisandra chinensis, effectively inhibits pancreatic cancer growth and proliferation. It works by inducing cell cycle arrest and apoptosis, and by targeting the Hippo-YAP pathway, offering a promising therapeutic avenue.

Area of Science:

  • Oncology
  • Pharmacology
  • Molecular Biology

Background:

  • Pancreatic cancer has a very low survival rate.
  • Gomisin G exhibits known anti-tumor properties.
  • Mechanisms of Gomisin G in pancreatic cancer are not well understood.

Purpose of the Study:

  • To investigate the anti-cancer effects of Gomisin G on pancreatic cancer.
  • To elucidate the underlying molecular mechanisms of Gomisin G action.

Main Methods:

  • Colony formation assay, flow cytometry, and western blot analysis.
  • Mouse xenograft model (PANC-1 tumors).
  • RNA-seq, qPCR, and confocal microscopy to analyze the Hippo-YAP pathway.

Main Results:

  • Gomisin G inhibited pancreatic cancer cell proliferation and colony formation.
  • It induced G1 phase arrest and apoptosis by modulating cell cycle regulators.
  • Gomisin G suppressed PANC-1 tumor growth in vivo.
  • It inhibited the Hippo-YAP pathway by promoting LATS1-mediated YAP phosphorylation and degradation.

Conclusions:

  • Gomisin G demonstrates significant anti-cancer activity against pancreatic cancer.
  • It acts through cell cycle arrest, apoptosis induction, and Hippo-YAP pathway inhibition.
  • Gomisin G is a potential therapeutic candidate for pancreatic cancer treatment.
Keywords:
Gomisin GLATS1YAPapoptosiscell cyclepancreatic cancer

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