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Gomisin G Inhibits Pancreatic Cancer Cell Growth by Promoting YAP Degradation
Lan Li1, Jiayu Chen2, Jiayi Shao2
1School of Public Health Wenzhou Medical University Wenzhou China.
Food Science & Nutrition
|July 26, 2026
Summary
Gomisin G, derived from Schisandra chinensis, effectively inhibits pancreatic cancer cell growth and tumor development. This natural compound shows promise as a potential therapeutic agent for pancreatic cancer by targeting key cell cycle and signaling pathways.
Area of Science:
- Oncology
- Pharmacology
- Molecular Biology
Background:
- Pancreatic cancer has a very low survival rate.
- Gomisin G exhibits known anti-tumor properties.
- The anti-cancer mechanisms of Gomisin G in pancreatic cancer are not well understood.
Purpose of the Study:
- To investigate the effects of Gomisin G on pancreatic cancer proliferation and apoptosis.
- To elucidate the molecular mechanisms underlying Gomisin G's anti-cancer activity.
- To evaluate Gomisin G's efficacy in a pancreatic cancer xenograft model.
Main Methods:
- Colony formation assay, flow cytometry, and western blot analysis were used to assess cell proliferation and apoptosis.
- A mouse xenograft model (PANC-1) was employed to evaluate in vivo tumor growth inhibition.
- RNA-sequencing (RNA-seq), quantitative real-time PCR (qPCR), and confocal microscopy were utilized to investigate the Hippo-YAP pathway.
Main Results:
- Gomisin G induced G1 phase arrest and apoptosis in pancreatic cancer cells by modulating cell cycle regulators (cyclin D1, p21, p27) and Rb activity.
- Gomisin G significantly inhibited PANC-1 tumor growth in vivo.
- Gomisin G promoted LATS1-mediated YAP phosphorylation, reduced YAP nuclear localization, and downregulated YAP target genes (CTGF, CYR61) in the Hippo-YAP pathway.
Conclusions:
- Gomisin G demonstrates significant anti-cancer activity against pancreatic cancer.
- Gomisin G exerts its effects by inducing cell cycle arrest, apoptosis, and inhibiting the Hippo-YAP pathway.
- Gomisin G is a potential therapeutic candidate for pancreatic cancer treatment.
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