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Utilization of Ultrasound Guided Tissue-directed Cellular Implantation for the Establishment of Biologically Relevant Metastatic Tumor Xenografts
Published on: May 25, 2018
Cellular xenotransplantation.
Alain J Poncelet1, Dufrane Denis, Pierre Gianello
1Laboratory of Experimental Surgery, Faculté de Médecine, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Brussels, Belgium.
Current Opinion in Organ Transplantation
|May 27, 2009
Summary
Cellular xenotransplantation shows promise for regenerative medicine, particularly in nonvascularized tissues. Further research into pig cells and immune responses is needed for broader clinical applications in treating diseases like diabetes and liver failure.
Area of Science:
- Regenerative Medicine
- Immunology
- Transplantation Biology
Background:
- Embryonic stem cells are unlikely for clinical use; postembryonic cells are key for regenerative medicine.
- Autologous, allogeneic, and xenogeneic cells are potential candidates for treating diseases.
- Cellular therapy holds significant promise for various medical applications.
Purpose of the Study:
- To review immunological and functional aspects of xenogeneic and allogeneic cellular transplantation.
- To explore applications in cardiomyopathy, diabetes, liver failure, neural diseases, and bone regeneration.
- To assess the potential of cellular xenotransplantation as a therapeutic tool.
Main Methods:
- Review of current knowledge on cellular transplantation.
- Analysis of immunological barriers and functional outcomes.
- Evaluation of encapsulation and immunosuppression strategies.
Main Results:
- Xenotransplantation is promising for immunologically privileged sites and nonvascularized tissues with minimal immunosuppression.
- Vascularized organ transplantation faces significant immune responses without conditioning.
- Encapsulation methods show positive results, and transgenic pig cells are strong candidates for xenotransplantation.
- Further research on pig cell immunity is necessary.
Conclusions:
- Cellular xenotransplantation is emerging as a viable therapeutic option in several medical fields.
- Encapsulation and immunosuppression strategies are crucial for successful xenotransplantation.
- Transgenic pig cells represent a promising source for human xenotransplantation.
