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Related Experiment Video

Updated: Jun 22, 2026

A Method for Determination and Simulation of Permeability and Diffusion in a 3D Tissue Model in a Membrane Insert System for Multi-well Plates

A Method for Determination and Simulation of Permeability and Diffusion in a 3D Tissue Model in a Membrane Insert System for Multi-well Plates

Published on: February 23, 2018

Aspects of skin permeability.

A Dyer¹, G G Hayes, J G Wilson

¹Department of Pure and Applied Chemistry, University of Salford, Salford, M5 4WT.

International Journal of Cosmetic Science

|May 28, 2009

Summary

Radiochemical monitoring revealed how salicylic acid penetrates pig and human skin. Factors like pH, temperature, and dimethyl formamide (DMF) concentration influence its diffusion, informing potential drug delivery mechanisms.

Area of Science:

Pharmacokinetics and Drug Delivery
Materials Science
Dermatology

Background:

Salicylic acid is a widely used pharmaceutical agent.
Understanding its skin penetration is crucial for topical drug formulation.
Variability in skin structure (e.g., whole, dermal, epidermal) affects diffusion.

Purpose of the Study:

To investigate the self-diffusion of salicylic acid across biological membranes.
To evaluate the impact of environmental factors (pH, temperature, DMF) on salicylic acid penetration.
To compare skin membrane diffusion with synthetic membranes like zeolites and polystyrenes.

Main Methods:

Radiochemical monitoring of salicylic acid diffusion.
Utilizing excised pig and human skin samples (whole, dermal, epidermal).

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Published on: February 23, 2018

Evaluating Vascular Hyperpermeability-inducing Agents in the Skin with the Miles Assay

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Visualizing and Quantifying Pharmaceutical Compounds within Skin using Coherent Raman Scattering Imaging

Visualizing and Quantifying Pharmaceutical Compounds within Skin using Coherent Raman Scattering Imaging

Published on: November 24, 2021

Systematic variation of pH, temperature, and dimethyl formamide (DMF) concentrations.

Main Results:

Salicylic acid self-diffusion was successfully quantified across different skin layers.
Penetration rates were significantly influenced by pH, temperature, and DMF concentration.
Distinct diffusion patterns were observed between biological and synthetic membranes.

Conclusions:

The study elucidates the primary mechanisms governing salicylic acid skin permeation.
Optimized conditions for salicylic acid delivery through skin can be inferred.
Findings provide insights for designing advanced drug delivery systems using synthetic materials.