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Circadian Rhythms and Gene Regulation

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...

Circadian Rhythms and Gene Regulation

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...

Biological Clocks and Seasonal Responses

Biological Clocks and Seasonal Responses

The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.

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Related Experiment Video

Updated: Jun 22, 2026

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

Fat circadian biology.

Jeffrey M Gimble¹, Z Elizabeth Floyd

¹Pennington Biomedical Research Center, Louisiana State Univ., Stem Cell Biology Laboratory, 6400 Perkins Rd., Baton Rouge, LA 70808, USA. gimblejm@pbrc.edu

Journal of Applied Physiology (Bethesda, Md. : 1985)

|May 28, 2009

Summary

Circadian rhythms regulate adipose tissue, impacting energy, fat, and glucose metabolism. Understanding this interplay is crucial for future adipose tissue physiology research.

Area of Science:

Endocrinology
Metabolism
Chronobiology

Background:

Adipose tissue, traditionally viewed for metabolism, is now recognized as an endocrine organ.
Emerging research highlights circadian mechanisms as key regulators of adipose tissue function.

Purpose of the Study:

To review recent data on the interplay between circadian regulators and adipose tissue.
To emphasize the role of circadian mechanisms in energy, fat, and glucose metabolism.

Main Methods:

Review of recent murine and human model data.
Focus on core circadian regulatory proteins and adipose tissue interactions.

Main Results:

Circadian mechanisms critically influence adipose tissue differentiation and metabolism.

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Rapid Analysis of Circadian Phenotypes in Arabidopsis Protoplasts Transfected with a Luminescent Clock Reporter

Rapid Analysis of Circadian Phenotypes in Arabidopsis Protoplasts Transfected with a Luminescent Clock Reporter

Published on: September 17, 2016

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Last Updated: Jun 22, 2026

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

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Published on: November 11, 2016

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells

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Published on: September 28, 2017

Rapid Analysis of Circadian Phenotypes in Arabidopsis Protoplasts Transfected with a Luminescent Clock Reporter

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Adipokine secretion is significantly regulated by circadian rhythms.

Interplay affects energy, fat, and glucose homeostasis.

Conclusions:

Circadian rhythms are integral to adipose tissue physiology.
Future research must incorporate circadian networks into understanding adipose tissue function.
This integration is vital for both health and disease contexts.