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Updated: Jun 22, 2026
08:46
Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model
Published on: September 29, 2011
Stability through the ages: the GSK experience
Zoe Blaxill1, Sue Holland-Crimmin, Rob Lifely
1Analytical Chemistry, GlaxoSmithKline, Harlow, UK. Zoe.Z.Blaxill@gsk.com
Journal of Biomolecular Screening
|May 28, 2009
Summary
Compound quality is crucial for drug discovery. GlaxoSmithKline studied compound stability in DMSO, identifying factors like concentration and storage conditions to optimize storage and handling practices for biological screening.
Area of Science:
- Pharmaceutical industry
- Drug discovery
- Chemical compound analysis
Background:
- Compound collection quality significantly impacts drug discovery success.
- Dimethyl sulfoxide (DMSO) is a common solvent for compound storage, but its hygroscopic nature can cause stability issues.
- Factors influencing compound stability include concentration, intrinsic stability, contaminants, storage format, conditions, and time.
Purpose of the Study:
- To define best practices for storing and handling solution samples.
- To enhance compound storage and use through understanding degradation.
- To support the implementation of automated liquid stores (ALS).
Main Methods:
- Over a decade of stability experiments.
- Utilized hyphenated liquid chromatography, electrospray mass spectrometry, flow chemiluminescence nitrogen detection, nuclear magnetic resonance, and Karl Fischer titration.
Main Results:
- Identified key factors affecting compound stability in solution.
- Provided data to establish optimal storage and handling protocols.
- Demonstrated the impact of various conditions on compound integrity.
Conclusions:
- Optimized storage and handling practices are essential for reliable biological screening.
- Understanding compound degradation pathways is critical for drug discovery.
- Best practices enhance the utility and longevity of compound libraries.
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