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A preliminary association study between brain-derived neurotrophic factor (BDNF) haplotype and late-onset depression
Jiayong You1, Yonggui Yuan, Zhijun Zhang
1Department of Psychiatry, Nanjing Medical University, Nanjing, 210029, China.
Objective:
The present study aimed to assess the association of genotypes and haplotypes in brain-derived neurotrophic factor (BDNF) polymorphisms with late-onset depression (LOD) in a Chinese Han population.
Method:
144 subjects with LOD and 110 control subjects were recruited for the study, assessed using the Hamilton Rating Scale for Depression, and genotyped for 712G/A, 270C/T, 196A/G and 11757G/C variants by polymerase chain reaction.
Results:
No differences were found in the frequencies of the alleles and genotypes of tested BDNF gene between LOD patients and normal group. Interestingly, the distributions of 712G-270T, 196A-11757G, 196G-11757C, 712G-196A-11757G, 712G-196G-11757C, 270C-196A-11757G, 270C-196G-11757C, 712G-270C-196A-11757G, 712G-270C-196G-11757C haplotypes were significantly higher in LOD compared to healthy controls (all P<0.05).
Conclusion:
The results tentatively suggest that BDNF haplotypes might be the susceptibility for LOD.
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