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Updated: Jun 22, 2026

Translating Extracellular Electron Transfer Activities with Organic Electrochemical Transistors

Translating Extracellular Electron Transfer Activities with Organic Electrochemical Transistors

Published on: January 31, 2025

Electronic interfacing with living cells.

James T Fleming¹

¹University of Tennessee, Center for Environmental Biotechnology, 676 Dabney Hall, Knoxville, 37996, TN, USA, jtf@utk.edu.

Advances in Biochemical Engineering/Biotechnology

|May 29, 2009

Summary

This summary is machine-generated.

This review explores bioelectronic devices that interface living cells with electronics. These systems enable monitoring of cellular signals and control of cellular processes using both microbial and mammalian cells.

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Silicon Microchips for Manipulating Cell-cell Interaction

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Published on: August 30, 2007

Area of Science:

Bioelectronic Interfaces
Cellular Engineering

Background:

Direct interfacing of living cells with inorganic electronic materials enables novel device functionalities.
Two primary device categories exist: biochemical-to-electrical signal transduction for monitoring and electrical-to-biochemical signal transduction for control.
Research spans both prokaryotic (microbial) and eukaryotic (mammalian) cell systems.

Purpose of the Study:

To survey the field of bioelectronic devices.
To highlight fundamental issues and obstacles in bioelectronic research.
To cover devices utilizing both microbial and mammalian cells.

Main Methods:

Review of existing literature and device applications.
Categorization of devices based on signal transduction direction (bio-to-electronic or electronic-to-bio).
Inclusion of diverse cell types (prokaryotic and eukaryotic).

Main Results:

Development of devices for monitoring living cells (e.g., biosensors).
Development of devices for controlling cellular processes (e.g., bioelectrical reactors).
Examples include microbial biofuel cells, bioelectrical reactors, living cell biosensors, and mammalian physiology monitoring/control devices.

Conclusions:

Bioelectronic interfaces offer significant potential for cell monitoring and control.
Fundamental challenges remain in optimizing these interfaces for robust applications.
The field encompasses a wide range of applications from energy generation to physiological regulation.