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Autoradiographic findings in experimental sinusitis in rabbits
J Kumlien1, P Stierna, H Schiratzki
1Dept. of O.R.L., Karolinska Institutet, Huddinge Hospital, Sweden.
Rhinology
|September 1, 1991
Summary
Purulent sinusitis increases radionuclide uptake in surrounding bone. Technetium-99m-labeled diphosphonate (99Tcm-DP) showed increased uptake in bone near infected sinus mucosa, indicating potential for diagnostic imaging.
Area of Science:
- Nuclear Medicine
- Otolaryngology
- Bone Metabolism
Background:
- Purulent sinusitis can affect surrounding tissues.
- Radionuclide uptake in bone can indicate metabolic changes.
Purpose of the Study:
- To investigate the impact of purulent sinusitis on radionuclide uptake in adjacent bone.
- To compare the efficacy of different radiopharmaceuticals for detecting these changes.
Main Methods:
- Experimental induction of acute and chronic unilateral maxillary sinusitis in animals.
- Intravenous administration of 45Ca-chloride or 99Tcm-DP.
- Autoradiographic and histological analysis 4-6 hours post-administration.
Main Results:
- Increased 99Tcm-DP uptake observed in bone surrounding infected sinus mucosa.
- Uptake detected as early as 4 days after acute sinusitis and 5 months after chronic sinusitis.
- No increased uptake noted in the infected sinus mucosa itself.
Conclusions:
- Purulent sinusitis enhances radionuclide uptake in the surrounding bone.
- 99Tcm-DP demonstrates potential for imaging bone changes associated with sinusitis.
- 45Ca-chloride showed limitations due to insufficient bone specificity.