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Updated: Jun 22, 2026

Pulling Membrane Nanotubes from Giant Unilamellar Vesicles
Published on: December 7, 2017
[Regulation of vesicular transport by membrane curvature]
Guillaume Drin1, Joëlle Bigay, Bruno Antonny
1Université de Nice Sophia Antipolis et CNRS, Institut de Pharmacologie moléculaire et cellulaire, UMR, Valbonne, France. drin@ipmc.cnrs.fr
Abstract:
A cellular membrane is highly deformable: during the last decade, numerous studies have dissected at the molecular scale how during vesicular transport various proteins could deform a membrane or recognize membrane deformation. We will discuss how the activity of ArfGAP1 and GMAP-210, two proteins involved in vesicular transport, is regulated by membrane curvature thanks to an ALPS motif. Since a membrane is not solely defined by its shape but also by its lipids composition, we will show how others proteins are adapted to other lipid compositions to recognize membrane shape.
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