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Related Concept Videos

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
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Chronic Pharyngitis01:23

Chronic Pharyngitis

Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
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Related Experiment Video

Updated: Jun 22, 2026

Methods for Detecting Cough and Airway Inflammation in Mice
04:33

Methods for Detecting Cough and Airway Inflammation in Mice

Published on: August 2, 2024

Postnasal drip and chronic cough: An open interventional study.

Patricia Macedo1, Hesham Saleh, Alfonso Torrego

  • 1Royal Brompton Hospital, Imperial College, London, UK.

Respiratory Medicine
|June 2, 2009
PubMed
Summary

Targeted treatment for rhinosinusitis associated with postnasal drip (PND) syndrome improved chronic cough in a pilot study. Further randomized controlled trials are needed to confirm these findings for cough relief.

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Last Updated: Jun 22, 2026

Methods for Detecting Cough and Airway Inflammation in Mice
04:33

Methods for Detecting Cough and Airway Inflammation in Mice

Published on: August 2, 2024

Area of Science:

  • Otolaryngology
  • Pulmonology
  • Allergy and Immunology

Background:

  • Postnasal drip (PND) syndrome is a debated cause of chronic cough.
  • Rhinosinusitis is frequently associated with PND and chronic cough.

Purpose of the Study:

  • To investigate the efficacy of topical rhinosinusitis treatment on chronic cough in patients with PND.
  • To assess the impact of treatment on PND symptoms and cough sensitivity.

Main Methods:

  • Open-label pilot study involving patients with chronic cough and PND.
  • Assessment of PND, cough, and rhinosinusitis using questionnaires, capsaicin challenge, nasal examination, and CT.
  • Treatment with fluticasone, ipratropium bromide, and azelastine nasal sprays for 28 days.

Main Results:

  • Mean cough scores significantly improved post-treatment (p<0.05).
  • Significant improvements observed in anterior nasal discharge (p=0.005) and endoscopic nasal scores (p<0.01).
  • No significant change in capsaicin cough sensitivity or nasal catarrh scores; a trend towards improved PND scores was noted.

Conclusions:

  • Topical treatment targeting rhinosinusitis in PND syndrome and chronic cough showed promising results in improving cough.
  • A pilot study suggests a potential therapeutic approach for chronic cough linked to PND.
  • Further randomized controlled trials are necessary to validate these findings.