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Related Concept Videos

Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...

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Related Experiment Video

Updated: Jun 22, 2026

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

Asthma genetics and genomics 2009.

Scott T Weiss1, Benjamin A Raby, Angela Rogers

  • 1Harvard Medical School, Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA. scott.weiss@channing.harvard.edu

Current Opinion in Genetics & Development
|June 2, 2009
PubMed
Summary
This summary is machine-generated.

Asthma genetic studies face challenges like small sample sizes and population stratification. Future research must consider gene interactions (epistasis) for clinical impact.

Related Experiment Videos

Last Updated: Jun 22, 2026

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

Area of Science:

  • Genetics
  • Pulmonology
  • Bioinformatics

Background:

  • Asthma genetic association studies are hindered by methodological issues common in complex trait research.
  • Despite challenges, 43 replicated genes have been identified, including TNF alpha, IL4, FCERB, Adam 33, and GSTP1.
  • Genes like ADAM33, DPP10, GPR154, PHF11, and ORMD3 have been identified through linkage, fine mapping, and genome-wide association studies (GWAS).

Purpose of the Study:

  • To review the current state of asthma genetics research.
  • To highlight the limitations of current methodologies in asthma genetics.
  • To emphasize the need for considering epistatic interactions in asthma genetics.

Main Methods:

  • Review of published asthma genetic association studies.
  • Identification of commonly replicated genes.
  • Analysis of genes identified through linkage, fine mapping, and GWAS.
  • Discussion of methodological challenges including sample size, replication, and population stratification.

Main Results:

  • 43 genes have been replicated in asthma association studies.
  • TNF alpha, IL4, FCERB, Adam 33, and GSTP1 are among the most frequently replicated genes.
  • A significant limitation is the focus on individual genes rather than their interactions.

Conclusions:

  • Current asthma genetics research has identified numerous genes but suffers from methodological flaws.
  • The field needs to move towards a more holistic approach, considering gene-gene interactions (epistasis).
  • Incorporating epistasis analysis is crucial for asthma genetics to translate into clinical applications.