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Related Experiment Video

Updated: Jun 22, 2026

Axon Stretch Growth: The Mechanotransduction of Neuronal Growth

Axon Stretch Growth: The Mechanotransduction of Neuronal Growth

Published on: August 10, 2011

Growth-attenuation therapy: principles for practice.

David B Allen¹, Michael Kappy, Douglas Diekema

¹Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, H4/448 CSC-Pediatrics, 600 Highland Ave, Madison, WI 53792-4108, USA. dballen@wisc.edu

|June 2, 2009

Summary

This summary is machine-generated.

Growth attenuation therapy, using high-dose estrogen, can improve quality of life for children with severe disabilities and their families. This safe and innovative treatment should be discussed with parents around age 3.

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Area of Science:

Pediatric Endocrinology
Bioethics
Developmental Disabilities

Background:

Families with children with profound disabilities face challenges managing physical size, impacting care and family inclusion.
Growth attenuation is a treatment option to manage physical size in children with severe disabilities.

Purpose of the Study:

To explore the scientific rationale, effectiveness, safety, and ethical considerations of growth attenuation therapy.
To provide informed responses to clinical questions regarding this treatment.

Main Methods:

Review of scientific literature and ethical considerations.
Analysis of the implications of growth attenuation for children with profound cognitive disability.

Main Results:

Growth attenuation is presented as an innovative and safe therapy.
The treatment offers potential for improved quality of life for nonambulatory children and their families.

Conclusions:

Pediatricians should discuss growth attenuation as part of anticipatory guidance around age 3.
Ethics consultation is recommended due to the controversial nature and public debate surrounding the therapy.