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Updated: Jun 22, 2026

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Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
Published on: July 19, 2019
Prominent brainstem and cerebellar involvement in multiple sclerosis with psoriasis
G Ganesvaran1, J M Greer, M P Pender
1Department of Neurology, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.
Summary
A subgroup of 20 patients with multiple sclerosis (MS) and psoriasis showed high rates of brainstem/cerebellar involvement and MS severity. Genetic factors may contribute to these findings in MS patients with psoriasis.
Area of Science:
- Neuroimmunology
- Dermatology
- Genetics
Background:
- Identified a subgroup of 20 patients with multiple sclerosis (MS) and psoriasis from a larger cohort of 692 MS patients.
- This subgroup exhibited distinct clinical and genetic characteristics.
Purpose of the Study:
- To investigate the clinical and genetic features of multiple sclerosis patients who also have psoriasis.
- To explore potential associations between these conditions and specific genetic markers.
Main Methods:
- Retrospective analysis of a cohort of multiple sclerosis patients.
- Clinical data review focusing on neurological involvement and disease severity.
- Human leukocyte antigen (HLA) typing to identify associated alleles.
Main Results:
- High incidence (80%) of brainstem and/or cerebellar involvement in the MS-psoriasis subgroup.
- Elevated mean Multiple Sclerosis Severity Score (6.06 +/- 2.88) in this subgroup.
- Significant carriage of MS-associated (DRB1*1501) and psoriasis-associated (DRB1*07) alleles.
Conclusions:
- The observed brainstem and cerebellar involvement may be linked to increased MS severity.
- High frequency of specific HLA alleles (DRB1*04, DRB1*07, DRB1*13) associated with brainstem/cerebellar involvement in MS patients with psoriasis.
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