Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Degenerative Disc Disease I: Introduction01:27

Degenerative Disc Disease I: Introduction

Degenerative disc disease is a chronic condition in which intervertebral discs gradually lose structure and function. It is not infectious or autoimmune; rather, it results from age-related biochemical and mechanical changes, influenced by genetic, metabolic, and environmental factors.Structure and Function of DiscsThe spine contains 23 intervertebral discs that absorb load, distribute forces, maintain spacing, and allow flexibility. Each disc consists of a nucleus pulposus, a gel-like core...
Herniated Intervertebral Disc l: Introduction01:29

Herniated Intervertebral Disc l: Introduction

Intervertebral disc herniation refers to the displacement of the nucleus pulposus (the gel-like inner core of the disc) through a tear or weakened area in the annulus fibrosus (the outer fibrous ring). The displaced disc material extends beyond the normal boundaries of the disc space and may compress or irritate nearby spinal nerve roots or, less commonly, the spinal cord.Etiology and Risk FactorsHerniation commonly results from degeneration, in which aging reduces disc hydration and...
Degenerative Disc Disease ll: Pathophysiology01:23

Degenerative Disc Disease ll: Pathophysiology

The symptoms of degenerative disc disease arise from a combination of mechanical compression, vascular compromise, and biochemical inflammation, which together disrupt nerve function and produce pain.Mechanical CompressionDisc degeneration reduces height and elasticity, predisposing to herniation of the nucleus pulposus, a major cause of radicular pain. Herniations may be protrusion (bulging with intact annulus), extrusion (nucleus extends beyond disc but remains connected), or sequestration...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prolonged sequential temozolomide in glioblastoma: A systematic review with exploratory quantitative synthesis.

Cancer treatment and research communications·2026
Same author

Bio-Inspired lipid nanovesicles (iNVs) incorporating membrane proteins from healthy tendon stem cells for targeted protein restoration in tendinopathic <i>in vitro</i> model.

Artificial cells, nanomedicine, and biotechnology·2026
Same author

Mechanical failure of modular hip stems due to titanium alloy neck breakage: a single-center case series.

Musculoskeletal surgery·2025
Same author

The use of bone-modifying agents in early breast cancer: AIOM Guidelines update and perspectives.

Tumori·2025
Same author

Transcultural adaptation and validation of the 4-Domain Sports PROM into Italian.

Journal of ISAKOS : joint disorders & orthopaedic sports medicine·2024
Same author

Survivorship of total knee arthroplasty in poliomyelitis patients: long-term results from the R.I.P.O. registry and single-institution retrospective study.

Archives of orthopaedic and trauma surgery·2024
Same journal

Comorbidities in Perthes' disease: a case control study using the General Practice Research database.

The Journal of bone and joint surgery. British volume·2012
Same journal

The treatment of complex tibial shaft fractures by the Ilizarov method.

The Journal of bone and joint surgery. British volume·2012
Same journal

Posterior spinal arthrodesis for adolescent idiopathic scoliosis using pedicle screw instrumentation: does a bilateral or unilateral screw technique affect surgical outcome?

The Journal of bone and joint surgery. British volume·2012
Same journal

Anterior deltoid deficiency in reverse total shoulder replacement: a biomechanical study with cadavers.

The Journal of bone and joint surgery. British volume·2012
Same journal

Long-term results of dorsal intercarpal ligament capsulodesis for the treatment of chronic scapholunate instability.

The Journal of bone and joint surgery. British volume·2012
Same journal

Medial patellofemoral ligament reconstruction for patellar instability in patients with hypermobility: a case control study.

The Journal of bone and joint surgery. British volume·2012
See all related articles

Related Experiment Video

Updated: Jun 22, 2026

Surgical Technique for the Implantation of a Biomimetic Artificial Intervertebral Disc in a Goat Animal Model
07:06

Surgical Technique for the Implantation of a Biomimetic Artificial Intervertebral Disc in a Goat Animal Model

Published on: October 10, 2025

Cervical spinal disc replacement.

V Denaro1, R Papalia, L Denaro

  • 1Department of Orthopaedic and Trauma Surgery, Campus Biomedico, University of Rome, Rome, Italy.

The Journal of Bone and Joint Surgery. British Volume
|June 2, 2009
PubMed
Summary
This summary is machine-generated.

Cervical disc replacement aims to preserve motion but its effectiveness is uncertain. Long-term studies are needed to determine if it offers advantages over fusion for degenerative cervical disc disease.

Related Experiment Videos

Last Updated: Jun 22, 2026

Surgical Technique for the Implantation of a Biomimetic Artificial Intervertebral Disc in a Goat Animal Model
07:06

Surgical Technique for the Implantation of a Biomimetic Artificial Intervertebral Disc in a Goat Animal Model

Published on: October 10, 2025

Area of Science:

  • Spine surgery
  • Orthopedic surgery
  • Biomedical engineering

Background:

  • Degenerative cervical disc disease is common.
  • Cervical disc replacement is an alternative to fusion.
  • The goal is to preserve motion and prevent adjacent segment disease.

Purpose of the Study:

  • To evaluate the effectiveness of cervical disc replacement.
  • To assess complications associated with cervical disc replacement.
  • To determine if cervical disc replacement is superior to fusion.

Main Methods:

  • Review of existing literature on cervical disc replacement.
  • Analysis of patient outcomes and complications.
  • Comparison with cervical fusion outcomes.

Main Results:

  • The effectiveness of cervical disc replacement remains uncertain.
  • Complications include ankylosis, ossification, neurological deficit, and device failure.
  • Adjacent segment degeneration may be part of natural disease progression.

Conclusions:

  • Strict patient selection and adherence to evidence are crucial.
  • Prospective, randomized trials with long-term follow-up are necessary.
  • The long-term advantage of cervical disc replacement over fusion is not yet established.