A concise synthesis of licochalcone E and its regio-isomer, licochalcone F
Younghwa Na1, Jeong-Heon Cha, Ho-Geun Yoon
1College of Pharmacy, Catholic University of Daegu, Gyeongsan, Gyeongbuk 712-702, Korea. yna7315@cu.ac.kr
Abstract:
Licochalone E is one of the retrochalcones isolated from Glycyrrhiza inflata which shows potent cytotoxicty against human tumor cell lines. Biological studies suggested that topoisomerase I inhibition correlates with cytotoxic properties. Other research revealed that licochalcone E modulats the nuclear factor (NF)-kB and Bcl-2 families to induce endothelial cell apoptosis. Since licochalcone E has been isolated recently, synthetic information on this compound has not been reported yet. Therefore we report the concise synthesis of licochalcone E and its regio-isomer, tentatively called licochalcone F, by employing Claisen rearrangement for key intermediate synthesis.
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