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Related Concept Videos

DNA Microarrays02:34

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...

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Related Experiment Video

Updated: Jun 22, 2026

Performing Custom MicroRNA Microarray Experiments
07:04

Performing Custom MicroRNA Microarray Experiments

Published on: October 28, 2011

Minimum Information About a Microarray Experiment (MIAME)--successes, failures, challenges.

Alvis Brazma1

  • 1Microarray Informatics Group, European Bioinformatics Institute, EMBl-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK. brazma@ebi.ac.uk

Thescientificworldjournal
|June 2, 2009
PubMed
Summary
This summary is machine-generated.

Minimum Information About a Microarray Experiment (MIAME) guidelines ensure clear interpretation of microarray data. New Minimum Information about a high-throughput SeQuencing Experiment (MINSEQE) guidelines are proposed for sequencing experiments.

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Fabrication and Use of MicroEnvironment microArrays (MEArrays)
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Fabrication and Use of MicroEnvironment microArrays (MEArrays)

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Last Updated: Jun 22, 2026

Performing Custom MicroRNA Microarray Experiments
07:04

Performing Custom MicroRNA Microarray Experiments

Published on: October 28, 2011

Fabrication and Use of MicroEnvironment microArrays (MEArrays)
11:57

Fabrication and Use of MicroEnvironment microArrays (MEArrays)

Published on: October 11, 2012

Area of Science:

  • Bioinformatics
  • Genomics
  • Molecular Biology

Background:

  • Microarray experiments require standardized reporting for unambiguous interpretation.
  • The Minimum Information About a Microarray Experiment (MIAME) guidelines facilitate data sharing and reusability.
  • Ensuring data utility is crucial for advancing scientific research.

Purpose of the Study:

  • To highlight the importance of standardized reporting in biological experiments.
  • To introduce the MIAME guidelines and their impact on microarray data.
  • To announce the development of new guidelines for high-throughput sequencing data.

Main Methods:

  • Review of existing MIAME guidelines.
  • Discussion of the principles behind standardized experimental reporting.
  • Proposal of draft MINSEQE guidelines.

Main Results:

  • MIAME guidelines have been successfully adopted, improving microarray data interpretation.
  • Standardized data reporting enhances the usefulness of experimental results.
  • Draft MINSEQE guidelines are under development by the MGED Society.

Conclusions:

  • Standardized reporting is essential for reproducible and interpretable biological research.
  • MIAME guidelines have demonstrably improved microarray data accessibility and utility.
  • The development of MINSEQE guidelines will extend these benefits to high-throughput sequencing data.