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Related Concept Videos

The Early Endosome: Endocytosis of Transferrin01:28

The Early Endosome: Endocytosis of Transferrin

Essential proteins such as insulin or low-density lipoprotein (LDL) and micronutrients such as iron enter a eukaryotic cell through receptor-mediated endocytosis. Subsequently, the early endosomes fuse with the vesicles containing such receptor-ligand complexes and play a vital role in sorting the incoming ligands and receptors. While the ligands are either degraded inside the vesicle or released into the cytosol, their receptors are returned to the plasma membrane for further rounds of...
Microbes and Other Elemental Cycles01:24

Microbes and Other Elemental Cycles

Microbial activity plays a pivotal role in the biogeochemical cycling of iron and manganese, especially at the redox gradients characteristic of stratified aquatic environments. These cycles are driven by microbial transformations between oxidized and reduced forms of the metals, allowing organisms to exploit them for metabolic energy and structural purposes.Iron Cycling Across Redox GradientsIn neutral, oxygen-rich surface waters, iron is predominantly found in its oxidized, insoluble ferric...
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Electron Transport Chain: Complex I and II01:46

Electron Transport Chain: Complex I and II

The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
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Electron Transport Chain: Complex III and IV01:43

Electron Transport Chain: Complex III and IV

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Related Experiment Video

Updated: Jun 22, 2026

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes
08:45

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes

Published on: May 10, 2022

Mammalian iron transport.

Gregory Jon Anderson1, Christopher D Vulpe

  • 1Iron Metabolism Laboratory, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, QLD, Australia. Greg.Anderson@qimr.edu.au

Cellular and Molecular Life Sciences : CMLS
|June 2, 2009
PubMed
Summary

Iron is vital for cells but toxic in excess. This study explains how cells regulate iron uptake and export, crucial for maintaining iron homeostasis and preventing toxicity.

Area of Science:

  • Biochemistry
  • Cell Biology
  • Physiology

Background:

  • Iron is essential for cellular functions but toxic at high concentrations, necessitating strict regulation.
  • Cellular iron uptake primarily occurs via transferrin-bound iron through transferrin receptor 1 and divalent metal-ion transporter 1.
  • Non-transferrin-bound iron uptake mechanisms remain incompletely understood.

Purpose of the Study:

  • To elucidate the mechanisms of cellular iron transport, including uptake and export.
  • To highlight the role of specific proteins in maintaining iron homeostasis.
  • To describe the systemic regulation of iron transport.

Main Methods:

  • Review of existing literature on iron transport proteins and pathways.
  • Analysis of the molecular interactions between iron transporters and regulatory factors.

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Last Updated: Jun 22, 2026

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes
08:45

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes

Published on: May 10, 2022

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Assessing Iron Deposition in the Brains of 5xFAD Mice by Perls'/DAB Staining

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Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay
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  • Integration of cellular and systemic iron regulation mechanisms.

    • Main Results:

    • Iron enters cells mainly bound to transferrin, involving transferrin receptor 1 and divalent metal-ion transporter 1.
    • Cells export iron using the ferroportin protein coupled with an iron oxidase.
    • Hepcidin, a liver peptide hormone, regulates systemic iron levels by controlling ferroportin activity.

    Conclusions:

    • Cellular iron transport is a tightly regulated process involving specific protein complexes.
    • Understanding these mechanisms is key to addressing iron overload or deficiency disorders.
    • Hepcidin plays a critical role in systemic iron balance by modulating cellular iron efflux.