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Murine Intrapulmonary Tracheal Transplantation: A Model for Investigating Obliterative Airway Disease After Lung Transplantation
Published on: November 10, 2023
[Intravascular lymphomatosis presenting in the lung]
Rui-E Feng1, Hong-Rui Liu, Wei-Xun Zhou
1Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China. feng.ruie@yahoo.com.cn
Summary
Intravascular lymphomatosis primarily in the lung is a rare cancer. Diagnosis requires lung biopsy, as symptoms mimic pneumonia, and T-cell cases show poor prognosis.
Area of Science:
- Pulmonology
- Oncology
- Pathology
Background:
- Intravascular lymphomatosis (IVL) is a rare extranodal non-Hodgkin lymphoma.
- This study focuses on IVL presenting primarily in the lungs, excluding skin and CNS involvement.
Observation:
- A case of T-cell IVL presented with fever and pulmonary shadows.
- Review of 14 similar cases revealed predominantly older male patients.
- Common symptoms included dyspnea, cough, fever, and weight loss.
Findings:
- Pulmonary function tests often showed decreased diffusing capacity.
- Chest CT scans revealed multiple reticular or nodular densities.
- B-cell IVL had a better prognosis than T-cell IVL, with T-cell cases showing poor outcomes.
Implications:
- Pulmonary IVL presents with nonspecific symptoms, mimicking interstitial pneumonia or infection.
- Diagnosis relies on pathological confirmation via lung biopsy (transbronchial or surgical).
- Early diagnosis and appropriate treatment are crucial, especially for T-cell IVL with its poor prognosis.
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