Related Experiment Video
Updated: Jun 22, 2026
06:23
A Murine Orthotopic Bladder Tumor Model and Tumor Detection System
Published on: January 12, 2017
CEACAM1: a novel urinary marker for bladder cancer detection
Derya Tilki1, Bernhard B Singer, Shahrokh F Shariat
1Department of Urology, University Hospital Grosshadern, Ludwig-Maximilians-University Munich, Germany. Derya.Tilki@med.uni-muenchen.de
European Urology
|June 3, 2009
Summary
Urinary Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) shows promise for detecting urothelial carcinoma of the bladder (UCB). Elevated CEACAM1 levels in urine correlate with cancer presence, stage, and grade.
Area of Science:
- Uro-oncology
- Biomarker Discovery
- Cancer Diagnostics
Background:
- Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is present in normal bladder urothelium and proangiogenic endothelial cells.
- CEACAM1 expression patterns change in urothelial carcinoma of the bladder (UCB).
Purpose of the Study:
- To evaluate the diagnostic value of urinary CEACAM1 for detecting urothelial carcinoma of the bladder (UCB).
Main Methods:
- Prospective study of 175 patients.
- Immunohistochemistry, Western blot, and ELISA for CEACAM1 in urine samples.
- Analysis of CEACAM1 levels in healthy volunteers and patients with UCB or other bladder conditions.
Main Results:
- Urinary CEACAM1 was detected in 76% of non-invasive UCB and 100% of invasive UCB patients, but not in healthy controls.
- ELISA showed significantly higher urinary CEACAM1 levels in UCB patients (median 207 ng/ml) vs. controls (0 ng/ml).
- The marker demonstrated an AUC of 0.870, with a cutoff of 110 ng/ml providing 74% sensitivity and 95% specificity for UCB detection.
Conclusions:
- Urinary CEACAM1 effectively distinguishes UCB patients from non-UCB individuals.
- CEACAM1 levels correlate with advancing UCB stage and grade, suggesting potential diagnostic and prognostic value.
- Further research is needed to establish the definitive roles of urinary CEACAM1 in UCB management.
Related Concept Videos
01:22Imaging Studies VI: Voiding Cystourethrography and Cystography
Voiding Cystourethrography (VCUG) and Cystography are specialized radiographic procedures used to examine the structure and function of the bladder and urethra.Voiding Cystourethrography (VCUG)A Voiding Cystourethrogram (VCUG) is a diagnostic imaging procedure that assesses the anatomy and function of the lower urinary tract. It focuses on the bladder, bladder neck, and urethra, helping detect abnormalities such as vesicoureteral reflux (VUR)—the backward or reverse flow of urine into the...
01:31Immunoglobulin-like Cell Adhesion Molecules
Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
01:23Urinary Bladder
The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...