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Related Concept Videos

Drug Therapy01:28

Drug Therapy

The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Behavior Therapy01:22

Behavior Therapy

Behavior therapy incorporates diverse techniques rooted in classical conditioning principles to address maladaptive behaviors and anxiety disorders. These methods aim to reduce avoidance behaviors, foster adaptive coping mechanisms, and alter associations between stimuli and responses, making them effective in a wide range of therapeutic contexts.
Exposure therapy is a cornerstone of behavioral treatment for anxiety disorders. It involves systematic exposure to feared stimuli, either in real...
Psychotherapy01:28

Psychotherapy

Psychotherapy is a versatile, nonmedical approach aimed at helping individuals address emotional, behavioral, and interpersonal issues to enhance their overall well-being. It can involve one-on-one sessions, couples counseling, or small group discussions with a therapist. The therapeutic process includes various techniques such as open discussion, interpretation of thoughts and behaviors, active listening, positive reinforcement, and role modeling. Psychotherapy aims to support individuals in...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

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Killer Artificial Antigen Presenting Cells (KaAPC) for Efficient In Vitro Depletion of Human Antigen-specific T Cells
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Killer Artificial Antigen Presenting Cells (KaAPC) for Efficient In Vitro Depletion of Human Antigen-specific T Cells

Published on: August 11, 2014

Adaptive therapy.

Robert A Gatenby1, Ariosto S Silva, Robert J Gillies

  • 1Department of Integrative Mathematical Oncology, Moffitt Cancer Center, Tampa, Florida 33612, USA. Robert.Gatenby@moffitt.org

Cancer Research
|June 3, 2009
PubMed
Summary
This summary is machine-generated.

Adaptive therapy, a novel cancer treatment strategy, maintains a stable tumor burden by allowing sensitive cells to suppress resistant ones, leading to prolonged survival compared to traditional methods.

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Area of Science:

  • Evolutionary Biology
  • Cancer Research
  • Mathematical Modeling

Background:

  • Cancer therapies often fail due to emergent resistant populations.
  • Tumor microenvironment and cancer cell adaptability drive treatment resistance.
  • Standard cancer therapy protocols are typically fixed and linear.

Purpose of the Study:

  • To examine an adaptive therapeutic approach for cancer treatment.
  • To model the evolutionary dynamics of tumor populations under therapy.
  • To compare adaptive therapy with conventional high-dose or metronomic therapies.

Main Methods:

  • Mathematical modeling and analysis of tumor population dynamics.
  • Computer simulations to evaluate treatment strategies.
  • In vivo experiments using OVCAR xenografts treated with carboplatin.

Main Results:

  • Maximum dose chemotherapy can accelerate the growth of resistant populations.
  • Adaptive therapy, by maintaining chemosensitive cells, suppresses resistant subpopulations.
  • Computer simulations predict prolonged survival with adaptive therapy.
  • In vivo experiments demonstrate the feasibility of adaptive therapy.

Conclusions:

  • Replacing a "treatment-for-cure" strategy with "treatment-for-stability" can maximize host survival.
  • Adaptive therapy offers a promising approach for prolonged cancer patient survival.
  • Maintaining a stable population of chemosensitive cells is key to controlling resistant tumor growth.