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Related Concept Videos

Classification of Leukocytes01:30

Classification of Leukocytes

Leukocytes are classified into two groups based on the presence or absence of cytoplasmic granules. Granular leukocytes, which contain granules, belong to the myeloid lineage and are divided into three subtypes: neutrophils, eosinophils, and basophils. These cells are roughly spherical and characterized by the granules in their cytoplasm.
Neutrophils are the most abundant type of granular leukocytes, comprising 50-70% of all leukocytes. They feature small, evenly distributed granules and a...
Disorders of Leukocytes01:27

Disorders of Leukocytes

Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...
Leishmaniasis01:30

Leishmaniasis

Leishmaniasis is a protozoal disease caused by species of the genus Leishmania and transmitted through the bite of infected female sandflies. The parasite exists in two principal morphological forms during its life cycle. A sandfly acquires intracellular amastigotes from an infected reservoir host, such as a dog. Within the sandfly, these forms differentiate into motile, flagellated promastigotes. During a subsequent blood meal, promastigotes are injected into the human host, where they...
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...

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Related Experiment Videos

[Large granular lymphocytic leukaemia].

Silje Michalsen1, Elisabeth Schrumpf, Klaus Beiske

  • 1Det medisinske fakultet, Universitetet i Oslo.

Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke
|June 3, 2009
PubMed
Summary
This summary is machine-generated.

Large granular lymphocytic leukaemia (LGL-leukaemia) is often under-diagnosed. Unexplained cytopenias may indicate LGL-leukaemia, prompting early diagnosis and effective treatment.

Related Experiment Videos

Area of Science:

  • Hematology
  • Oncology
  • Immunology

Context:

  • Large granular lymphocytic leukaemia (LGL-leukaemia) is a rare hematologic malignancy.
  • While typically T-cell in origin, a subset exhibits an NK-cell phenotype.
  • The true incidence and prevalence remain largely unknown.

Purpose:

  • To investigate the incidence and clinical characteristics of LGL-leukaemia.
  • To assess the diagnostic challenges and potential for under-diagnosis.

Summary:

  • A retrospective study identified 52 LGL-leukaemia patients (T-cell: 51, NK-cell: 1) between 2001-2007.
  • Common presentations included asymptomatic disease or cytopenias (e.g., neutropenia).
  • Significant comorbidities included autoimmune diseases (common) and clonal B-cell disorders (17%).

Impact:

  • Findings suggest LGL-leukaemia is under-diagnosed.
  • Unexplained cytopenias warrant investigation for LGL-leukaemia.
  • Early diagnosis facilitates appropriate treatment and avoids extensive work-ups.