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Updated: Jun 22, 2026

Fluorescence-quenching of a Liposomal-encapsulated Near-infrared Fluorophore as a Tool for In Vivo Optical Imaging
Published on: January 5, 2015
MicroPET, MicroSPECT, and NIR fluorescence imaging of biomolecules in vivo
1Department of Radiology, Stanford University School of Medicine, 94305-5484, Stanford, CA, USA.
Abstract:
Molecular imaging is a newly merged multidisciplinary subject that requires contributions from biology, medical physics, and chemistry/radiochemistry. Integrin alpha(v)beta(3), a cell adhesion molecule, plays pivotal roles in regulating tumor angiogenesis and the growth of new blood vessels. In this chapter, we use the cell adhesion molecule integrin alpha(v)beta(3) as an example to demonstrate how one can synthesize appropriate arginine-glycine-aspartic acid (RGD) peptide-containing probes for visualizing and quantifying the receptor expression in vivo by means of microPET, microSPECT, and NIR fluorescence.
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