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Related Concept Videos

Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists01:27

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5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
Antiepileptic Drugs: Potassium Channel Activators01:20

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Ezocgabine or retigabine, an antiepileptic drug of remarkable efficacy, has revolutionized the management of seizures. It is a potassium channel activator, explicitly targeting the family of Q subtype potassium channels. It enhances the transmembrane potassium currents, regulating neuronal excitability. This action stabilizes the resting membrane potential, a pivotal factor in mitigating the hyperexcitability that characterizes epilepsy.
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Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates these...
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Serotonin, a crucial neurotransmitter synthesized by enterochromaffin cells, plays a cardinal role in regulating gastrointestinal (GI) motility. With over 90% of the body's total serotonin in the GI tract, its influence on digestive processes is profound. Serotonin is swiftly released upon various stimuli, such as food boluses or certain drugs, triggering intrinsic sensory neurons in the myenteric plexus and extrinsic vagal and spinal sensory neurons. This leads to the activation of the...
Seizures: Classification01:13

Seizures: Classification

Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
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Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:

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Updated: Jun 22, 2026

Seizure Activity Induced by Electroshock in Drosophila Larvae
06:10

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Published on: June 6, 2025

Ondansetron and seizures.

Niranjan N Singh1, Ajitesh Rai, John B Selhorst

  • 1Department of Neurology, University of Missouri, Columbia, Missouri, USA. singhn@health.missouri.edu

Epilepsia
|June 4, 2009
PubMed
Summary
This summary is machine-generated.

Ondansetron, a 5-HT(3) receptor antagonist, may trigger seizures in susceptible individuals. This case series highlights three patients experiencing seizures shortly after ondansetron administration, with no recurrence observed.

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Clinical Neurology

Background:

  • 5-hydroxytryptamine (5-HT) receptors are implicated in epileptogenesis.
  • Ondansetron, a 5-HT(3) receptor antagonist, exhibits variable effects on seizures in animal models.
  • The potential for ondansetron to induce seizures in humans requires further investigation.

Purpose of the Study:

  • To report cases of seizures occurring after ondansetron administration.
  • To investigate the potential causal link between ondansetron and seizure induction.

Main Methods:

  • Case series describing three patients who experienced seizures post-ondansetron.
  • Clinical assessment including electroencephalography (EEG) and magnetic resonance imaging (MRI).
  • Evaluation of seizure recurrence after ondansetron cessation.

Main Results:

  • Three patients (2 female, 1 male; ages 38-56) developed generalized tonic-clonic seizures 12-22 minutes after intravenous ondansetron (4 mg).
  • None had prior seizure history or family history of epilepsy.
  • EEG and MRI were normal; no seizures recurred after discontinuation of ondansetron.

Conclusions:

  • The temporal association and lack of recurrence suggest ondansetron may have triggered seizures in these patients.
  • Ondansetron should be used cautiously in patients with potential seizure risk factors.
  • Further research is warranted to elucidate the mechanism of ondansetron-induced seizures.