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Updated: Jun 22, 2026

Mouse Kidney Transplantation: Models of Allograft Rejection
Published on: October 11, 2014
Recurrence of granulomatous interstitial nephritis in transplanted kidney
Federico Vargas1, Abraham Gedalia, Randall D Craver
1Departments of Pediatrics and Pathology, Children's Hospital and Louisiana Health Sciences Center, New Orleans, LA 70118,USA.
Abstract:
Sarcoidosis is a multisystemic disease of unknown etiology. Minor renal involvement is not rare but kidney failure is uncommon and only rare cases of recurrent disease in a kidney transplant have been published. We report a patient who at age 10 yr developed ESRD secondary to renal sarcoidosis with GIN. Her disease subsequently recurred in the transplanted kidney despite standard immunosuppression with prednisone, tacrolimus, and mycophenolate mofetil. The recurrent disease appeared to respond to increased immunosuppression, which included infliximab. However, the patient died of disseminated histoplasmosis three yr post-transplant.
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