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Related Experiment Video

Updated: Jun 22, 2026

Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials
08:41

Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials

Published on: August 13, 2019

Vertical ridge augmentation using xenogenous bone blocks: a histomorphometric study in dogs.

Daniel Rothamel1, Frank Schwarz, Monika Herten

  • 1Department of Oral Surgery, Heinrich Heine University, Düsseldorf, Germany. daniel.rothamel@uk-koeln.de

The International Journal of Oral & Maxillofacial Implants
|June 5, 2009
PubMed
Summary

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Screwable xenogenous bone blocks show potential for vertical ridge augmentation, performing similarly to autologous bone blocks in canine studies. Combining xenogenous blocks with collagen membranes did not enhance healing outcomes.

Area of Science:

  • Oral and Maxillofacial Surgery
  • Regenerative Dentistry
  • Biomaterials Science

Background:

  • Vertical ridge augmentation is crucial for dental implant success.
  • Autologous bone blocks carry risks of graft resorption and donor site morbidity.
  • Xenogenous bone blocks offer an alternative but require histological evaluation.

Purpose of the Study:

  • To histologically compare healing after vertical ridge augmentation using screwable xenogenous deproteinized blocks versus autologous bone blocks in dogs.
  • To evaluate the osteoconductive properties and integration of xenogenous bone blocks.
  • To assess the effect of a collagen membrane on xenogenous block healing.

Main Methods:

  • Standardized vertical mandibular defects were created in six foxhounds.

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Surgical Angiogenesis in Porcine Tibial Allotransplantation: A New Large Animal Bone Vascularized Composite Allotransplantation Model
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Surgical Angiogenesis in Porcine Tibial Allotransplantation: A New Large Animal Bone Vascularized Composite Allotransplantation Model

Published on: August 13, 2017

Related Experiment Videos

Last Updated: Jun 22, 2026

Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials
08:41

Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials

Published on: August 13, 2019

Surgical Angiogenesis in Porcine Tibial Allotransplantation: A New Large Animal Bone Vascularized Composite Allotransplantation Model
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Surgical Angiogenesis in Porcine Tibial Allotransplantation: A New Large Animal Bone Vascularized Composite Allotransplantation Model

Published on: August 13, 2017

  • Xenogenous or autologous bone blocks were placed and fixed with titanium implants and screws.
  • Histomorphometric analysis was performed after 6 months of submerged healing.

    • Main Results:

    • Xenogenous blocks, alone or with a collagen membrane, demonstrated osteoconductive properties comparable to autologous blocks.
    • Ossification of blocks ranged from 50% to 60% across groups.
    • All groups exhibited signs of bone/graft resorption; inflammatory reactions occurred in some sites.

    Conclusions:

    • Screwable xenogenous bone blocks may serve as a viable scaffold for ridge augmentation.
    • The addition of a cross-linked collagen membrane did not improve the outcomes of xenogenous block augmentation.
    • Further research is needed to optimize xenogenous bone block integration and minimize resorption.