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Quantitative 35Cl nuclear quadrupole resonance in tablets of the antidiabetic medicine Diabinese
Elizabeth Tate1, Kaspar Althoefer, Jamie Barras
1King's College London, Department of Mechanical Engineering, Strand, London, WC2R 2LS, United Kingdom.
Abstract:
Pulsed (35)Cl nuclear quadrupole resonance (NQR) experiments have been performed on 250-mg tablets of the antidiabetic medicine Diabinese to establish the conditions needed for noninvasive quantitative analysis of the medicine in standard bottles. One important condition is the generation of a uniform radio-frequency (RF) field over the sample, which has been achieved by two designs of sample coil: one of variable pitch, and the other a resonator that has been fabricated from a single turn of copper sheet with a longitudinal gap bridged by tuning capacitors. The results from blind tests show that the number of tablets in a bottle could be predicted to within +/-3%.
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