Related Experiment Video
Updated: Jun 22, 2026

Surgical Techniques for Catheter Placement and 5/6 Nephrectomy in Murine Models of Peritoneal Dialysis
Published on: July 19, 2018
Peritoneal dialysis: a biological membrane with a nonbiological fluid
Abstract:
During chronic peritoneal dialysis (PD), the peritoneal membrane undergoes structural and functional alterations that, in some patients, may eventually lead to loss of function as the 'dialysis membrane'. These alterations include loss of mesothelial cells, thickening of the submesothelial compact zone, and changes of vascularization. At least some of these effects are thought to be associated with chronic exposure to unphysiological PD fluids. On a cellular level, chronic PD is associated with the phenomenon of epithelial-to-mesenchymal transformation (EMT) as well as premature aging and senescence of mesothelial cells. The present article discusses the potential mechanisms involved in these phenomena and reviews the current information derived from cell culture and animal studies.
Related Concept Videos
Peritoneal Dialysis I: Introduction and Procedure
Dialysis
Dialysis
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications
Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis
Hemodialysis I: Introduction
