Related Experiment Video
Updated: Jun 22, 2026
19:57
The Use of Trace Eyeblink Classical Conditioning to Assess Hippocampal Dysfunction in a Rat Model of Fetal Alcohol Spectrum Disorders
Published on: August 5, 2017
[Fetal malformations in women with epilepsy]
Akusherstvo I Ginekologiia
|June 6, 2009
Summary
This study found that 4.76% of pregnancies in women with epilepsy resulted in fetal malformations, predominantly neural tube defects. Pregnant women with epilepsy require careful monitoring and informed discussion regarding antiepileptic drug risks.
Area of Science:
- Obstetrics and Gynecology
- Neurology
- Teratology
Context:
- Epilepsy in pregnancy presents significant risks.
- Antiepileptic drugs (AEDs) carry teratogenic potential.
- Monitoring fetal development is crucial for high-risk pregnancies.
Purpose:
- To determine the incidence and characteristics of fetal malformations in women with epilepsy.
- To assess the teratogenic risk associated with AEDs in pregnant epileptic women.
Summary:
- A 12-year prospective study (1996-2007) followed 107 pregnant women with epilepsy.
- Fetal malformations occurred in 4.76% of cases, with neural tube defects being most common.
- Valproates and carbamazepine were the AEDs used by affected mothers.
Impact:
- Highlights the need for enhanced prenatal surveillance in epileptic pregnancies.
- Emphasizes the importance of comprehensive counseling on AED benefits and risks.
- Informs clinical practice regarding the management of epilepsy during pregnancy.
More Related Videos
Related Concept Videos
01:07Teratogenicity
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
01:24Epilepsy and Seizures: Overview
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
01:22Epilepsy ll: Types
Recurrent seizures, stemming from abnormal electrical activity in the brain, are the defining characteristic of epilepsy, a chronic neurological condition. Because seizure features vary greatly, epilepsy is classified using two systems: by seizure type and by epilepsy syndromes. These classifications enable clinicians to describe seizure patterns and select suitable treatment strategies.I. Classification by Seizure Type1. Focal EpilepsyFocal epilepsy begins in one hemisphere of the brain.
01:13Seizures: Classification
Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
02:57Meiosis vs. Mitosis
Cell division is necessary for growth and reproduction in organisms. Mitosis aids cell growth and development by dividing somatic cells. In contrast, meiosis causes the division of germ cells and plays an essential role in sexual reproduction. Due to their unique functional requirements, mitosis and meiosis differ from each other in multiple aspects.
Before the start of mitosis and meiosis I, the cell synthesizes DNA, resulting in two homologous copies of each chromosome. DNA synthesis is...
Before the start of mitosis and meiosis I, the cell synthesizes DNA, resulting in two homologous copies of each chromosome. DNA synthesis is...