Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 22, 2026

Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids
08:22

Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids

Published on: August 11, 2017

Vascularization strategies for tissue engineering.

Michael Lovett1, Kyongbum Lee, Aurelie Edwards

  • 1Department of Biomedical Engineering, Tufts University, Medford, Massachusetts 02155, USA.

Tissue Engineering. Part B, Reviews
|June 6, 2009
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Age-Related Adaptations in Renal Tubular Function in Female Rats.

Acta physiologica (Oxford, England)·2026
Same author

Heat waves elevate risks of airway hypersensitivity that inhaled endogenous ions reduce.

Research square·2025
Same author

Life in the fast lane: Functional consequences of male-female dynamic differences in the renal auto-regulation of flow.

bioRxiv : the preprint server for biology·2025
Same author

Global warming risks dehydrating and inflaming human airways.

Communications earth & environment·2025
Same author

Flow-dependent transport processes 2024: filtration, absorption, and secretion.

American journal of physiology. Renal physiology·2025
Same author

Effect of sex chromosome complement versus gonadal hormones on abundance of renal transporters.

American journal of physiology. Renal physiology·2025

Tissue engineering faces vascularization challenges, limiting construct size and in vivo integration. This review explores current strategies for creating vascularized tissues, assessing their effectiveness.

Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Vascularization is a critical limitation in tissue engineering, hindering nutrient and oxygen transport.
  • Current engineered tissues are restricted to small dimensions due to perfusion and mass transport limitations.
  • Successful vascularization is essential for clinical relevance and in vivo integration of engineered tissues.

Purpose of the Study:

  • To review and assess prevailing strategies for achieving vascularization in tissue engineering.
  • To highlight the strengths and weaknesses of various vascularization approaches.
  • To provide a quantitative perspective on oxygen diffusion and consumption in engineered tissues.

Main Methods:

  • Literature review of current tissue engineering vascularization techniques.

More Related Videos

Tissue Engineering by Intrinsic Vascularization in an In Vivo Tissue Engineering Chamber
09:55

Tissue Engineering by Intrinsic Vascularization in an In Vivo Tissue Engineering Chamber

Published on: May 30, 2016

A Full Skin Defect Model to Evaluate Vascularization of Biomaterials In Vivo
07:56

A Full Skin Defect Model to Evaluate Vascularization of Biomaterials In Vivo

Published on: August 28, 2014

Related Experiment Videos

Last Updated: Jun 22, 2026

Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids
08:22

Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids

Published on: August 11, 2017

Tissue Engineering by Intrinsic Vascularization in an In Vivo Tissue Engineering Chamber
09:55

Tissue Engineering by Intrinsic Vascularization in an In Vivo Tissue Engineering Chamber

Published on: May 30, 2016

A Full Skin Defect Model to Evaluate Vascularization of Biomaterials In Vivo
07:56

A Full Skin Defect Model to Evaluate Vascularization of Biomaterials In Vivo

Published on: August 28, 2014

  • Analysis of approaches including material functionalization, scaffold design, and microfabrication.
  • Examination of bioreactor development, cell seeding, and modular assembly methods.

    • Main Results:

    • Identified diverse strategies for engineered tissue vascularization.
    • Highlighted limitations in nutrient perfusion and oxygen diffusion across different methods.
    • Discussed the importance of modeling and measurement in assessing vascularization strategies.

    Conclusions:

    • Current tissue engineering vascularization methods have inherent strengths and weaknesses.
    • Overcoming mass transport limitations is key to developing clinically relevant engineered tissues.
    • Further research is needed to optimize vascularization for successful tissue integration and function.