Related Experiment Video
Updated: Jun 22, 2026

Intranasal Delivery of mRNA Polyplexes via Rayleigh Breakup Aerosols: An In Vitro Method for Nasal Deposition and Functional Testing
Published on: January 20, 2026
Dry powder nasal vaccines as an alternative to needle-based delivery
Anthony J Hickey1, Robert J Garmise
1School of Pharmacy, The University of North Carolina, Chapel Hill, NC 27599-7360, USA. ahickey@unc.edu
Abstract:
Drug delivery to the nasal cavity has been achieved using a variety of systems. Dry powder vaccines offer the advantages of chemical and physical stability in comparison to liquid formulations. An intranasal vaccine can elicit both a local and systemic immune response. Mucoadhesive compounds can extend the residence time for powder formulations on the nasal mucosa, potentially increasing the immune response. Manufacture and characterization of a formulation containing particles of a dry powder vaccine are discussed.
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