Hepatitis B and C in dialysis units in Kosova

Skender Telaku1, Hajrullah Fejza, Ymer Elezi

  • 1Gastroenterology Unit, University Clinical Center of Kosova, Prishtina, Republic of Kosova. skendert@hotmail.com

Virology Journal
|June 6, 2009
PubMed

Insights

Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are highly prevalent in Kosovan hemodialysis (HD) patients, with rates of 12% and 43% respectively. These findings highlight the critical need for improved infection control measures in HD units.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Epidemiology

Background:

  • Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections significantly contribute to morbidity and mortality in hemodialysis (HD) patients.
  • Understanding the prevalence and characteristics of these viral infections is crucial for patient management in end-stage kidney disease (ESKD).

Purpose of the Study:

  • To investigate the epidemiological and clinical features of HCV and HBV infections among ESKD patients undergoing maintenance HD in Kosova.
  • To determine the prevalence rates of HBV and HCV in six different HD units across Kosova.

Main Methods:

  • A cross-sectional study involving 583 ESKD patients on maintenance HD from six centers in Kosova.
  • Data collection included patient demographics, primary causes of ESKD, and serological markers for HBV (HBsAg) and HCV (anti-HCV antibody).
  • Serological markers were determined using the immunoenzymatic assay (ELISA) method.

Main Results:

  • The prevalence of HBsAg (HBV) was 12%, and the prevalence of anti-HCV antibody (HCV) was 43% among the studied HD patients.
  • Chronic nephritis was identified as the most frequent cause of ESKD in this population.
  • A significant proportion (23.5%) of ESKD cases had an unknown etiology.

Conclusions:

  • The prevalence of HBV and HCV infections remains high among hemodialysis patients in Kosova.
  • These findings underscore the urgent necessity for stringent adherence to infection control protocols, barrier precautions, and preventive strategies in all HD units.
  • Enhanced surveillance and intervention programs are required to mitigate the impact of viral hepatitis in this vulnerable patient group.
Abstract

Related Concept Videos

Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
Hemodialysis I: Introduction01:25

Hemodialysis I: Introduction

Hemodialysis (HD) is a medical treatment that artificially removes waste products, excess fluids, and toxins from the blood when the kidneys are no longer able to perform these functions effectively. In this process, blood is filtered through a semipermeable membrane, allowing for the selective removal of waste while preserving necessary components like blood cells and proteins. Hemodialysis is typically performed in patients with end-stage renal disease (ESRD) or severe kidney...
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Hemodialysis II: Procedure and Complications01:24

Hemodialysis II: Procedure and Complications

DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
Viral Hepatitis I: Introduction01:28

Viral Hepatitis I: Introduction

Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...
Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy01:26

Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy (CRRT) is an essential intervention for patients experiencing severe kidney dysfunction. This therapy offers a continuous mechanism for removing fluids and toxins from the bloodstream, leveraging the patient’s blood pressure to facilitate filtration through a specialized filter. This method contrasts with intermittent dialysis, providing a gentler and more consistent removal of waste products and excess fluid, which is particularly beneficial in critically...