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Real-Time Polymerase Chain Reaction-Based Detection and Quantification of Hepatitis B Virus DNA
Published on: December 15, 2023
Hepatitis B and C in dialysis units in Kosova
Skender Telaku1, Hajrullah Fejza, Ymer Elezi
1Gastroenterology Unit, University Clinical Center of Kosova, Prishtina, Republic of Kosova. skendert@hotmail.com
Insights
Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are highly prevalent in Kosovan hemodialysis (HD) patients, with rates of 12% and 43% respectively. These findings highlight the critical need for improved infection control measures in HD units.
Area of Science:
- Nephrology
- Infectious Diseases
- Epidemiology
Background:
- Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections significantly contribute to morbidity and mortality in hemodialysis (HD) patients.
- Understanding the prevalence and characteristics of these viral infections is crucial for patient management in end-stage kidney disease (ESKD).
Purpose of the Study:
- To investigate the epidemiological and clinical features of HCV and HBV infections among ESKD patients undergoing maintenance HD in Kosova.
- To determine the prevalence rates of HBV and HCV in six different HD units across Kosova.
Main Methods:
- A cross-sectional study involving 583 ESKD patients on maintenance HD from six centers in Kosova.
- Data collection included patient demographics, primary causes of ESKD, and serological markers for HBV (HBsAg) and HCV (anti-HCV antibody).
- Serological markers were determined using the immunoenzymatic assay (ELISA) method.
Main Results:
- The prevalence of HBsAg (HBV) was 12%, and the prevalence of anti-HCV antibody (HCV) was 43% among the studied HD patients.
- Chronic nephritis was identified as the most frequent cause of ESKD in this population.
- A significant proportion (23.5%) of ESKD cases had an unknown etiology.
Conclusions:
- The prevalence of HBV and HCV infections remains high among hemodialysis patients in Kosova.
- These findings underscore the urgent necessity for stringent adherence to infection control protocols, barrier precautions, and preventive strategies in all HD units.
- Enhanced surveillance and intervention programs are required to mitigate the impact of viral hepatitis in this vulnerable patient group.
Background:
Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are important causes of morbidity and mortality of hemodialysis (HD) patients. This study aimed to investigate the epidemiological and clinical features of HCV and HBV infections in six different HD units in Kosova.Five hundred and eighty-three end-stage kidney disease (ESKD) patients on maintenance HD from six HD centers in Kosova (358 female, 225 male, mean age 54,8 years (16-66) were included in this study. Data from databank of the National Blood Bank in Prishtina, as well as the data from the databank of the Transfusion Centers in Regional hospitals in Prizren, Peja, Gjilan, Mitrovica and Gjakova were taken in this study. Clinical data such as age, sex, HBsAg and anti-HCV antibody and primary causes of ESKD were examined.Serological markers for HBV and HCV were determined with immunoenzymatic assay (ELISA).
Results:
The T-test and x2 test were used to analyze the significance of the results. Among our HD patients HBsAg and anti-HCV antibody prevalence rate was 12%, respectively 43%. Chronic nephritis was a more frequent cause of ESKD among our HD patients. With unknown etiology were 23, 5% from them.
Conclusion:
HBV and HCV prevalence in our HD patients is still high. These data emphasize the need for stricter adherence to infection control, barrier precaution and preventive behaviors with all patients.
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