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Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections

Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections

Published on: August 30, 2014

Two year sublingual immunotherapy affects serum leptin.

Giorgio Ciprandi¹, Mara De Amici, Mariangela Tosca

¹Department of Internal Medicine, Azienda Ospedaliera Universitaria San Martino-University of Genoa, Genoa, Italy. giocip@unige.it

International Immunopharmacology

|June 6, 2009

Summary

Two courses of sublingual immunotherapy (SLIT) significantly increased serum leptin levels in males with allergic rhinitis. This finding suggests SLIT may alter leptin, a hormone previously linked to allergic rhinitis.

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Area of Science:

Immunology
Allergology
Endocrinology

Background:

Elevated serum leptin is observed in females with allergic rhinitis.
A single course of sublingual immunotherapy (SLIT) has not shown an effect on serum leptin levels.

Purpose of the Study:

To investigate serum leptin level changes in patients with pollen-induced allergic rhinitis.
To assess these changes before and after two pre-seasonal SLIT courses.

Main Methods:

Included 41 allergic rhinitis patients and 34 healthy controls.
Measured serum leptin levels before and after the second SLIT course.
Allergic rhinitis patients were responders to SLIT.

Main Results:

Serum leptin levels significantly increased in males after two SLIT courses (p=0.0056).
No significant changes were observed in females.

Conclusions:

At least two pre-seasonal SLIT courses are needed to significantly alter serum leptin levels.
This alteration was observed exclusively in males.
Further research is needed to understand the potential protective role of leptin.