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Predictive value of plasma B-type natriuretic peptide for ischemic stroke: a community-based longitudinal study
Tomohiro Takahashi1, Motoyuki Nakamura, Toshiyuki Onoda
1Division of Cardiology, Department of Internal Medicine, Iwate Medical University, Morioka, Japan. ttomo@ruby.ocn.ne.jp
Atherosclerosis
|June 6, 2009
Summary
Elevated plasma B-type natriuretic peptide (BNP) levels predict future ischemic stroke risk in men. This finding emerged from a large community study analyzing cardiovascular health and stroke incidence over nearly three years.
Area of Science:
- Cardiovascular Medicine
- Neurology
- Biomarkers
Background:
- Structural heart diseases, including atrial fibrillation, are known precursors to ischemic stroke.
- Plasma B-type natriuretic peptide (BNP) levels are elevated in various structural heart diseases.
- The predictive capacity of plasma BNP for ischemic stroke risk in the general population is not well-established.
Purpose of the Study:
- To investigate the predictive value of plasma BNP for the future development of ischemic stroke in community-dwelling adults.
- To assess the relationship between baseline plasma BNP levels and incident ischemic stroke.
- To determine if plasma BNP can serve as a biomarker for stroke risk stratification.
Main Methods:
- A community-based cohort study involving 13,466 participants from the general population.
- Baseline assessment included plasma BNP levels and cardiovascular risk factors.
- Ischemic stroke incidence was tracked via regional stroke registry data over a mean follow-up of 2.8 years.
- Multivariate Cox regression analysis was employed to evaluate the association between plasma BNP and stroke risk.
Main Results:
- A total of 102 participants experienced a first ischemic stroke during the follow-up period.
- In men, elevated plasma BNP levels (highest quartile) were significantly associated with an increased risk of ischemic stroke (HR=2.38) after adjusting for cardiovascular risk factors and atrial fibrillation.
- In women, the association between plasma BNP and ischemic stroke risk showed marginal statistical significance (HR=3.03, P=0.09) after similar adjustments.
Conclusions:
- Elevated plasma BNP levels are a significant predictor of ischemic stroke risk in men residing in the general community.
- Plasma BNP may serve as a valuable biomarker for identifying men at higher risk of stroke.
- Further research may be warranted to clarify the predictive role of BNP in women.
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