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Updated: Jun 22, 2026

A Porcine Heterotopic Heart Transplantation Protocol for Delivery of Therapeutics to a Cardiac Allograft
08:30

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Published on: February 14, 2022

Heart transplantation.

Takeshi Nakatani1

  • 1Department of Organ Transplantation, National Cardiovascular Center, Suita, Japan. tnakatan@hsp.ncvc.go.jp

Circulation Journal : Official Journal of the Japanese Circulation Society
|June 6, 2009
PubMed
Summary

Japan

Area of Science:

  • Cardiovascular Surgery
  • Transplantation Medicine

Background:

  • Since 1997, Japan has performed 59 heart transplantations (HTx).
  • Most recipients had dilated cardiomyopathy and were status 1, with a mean wait time of 777 days.
  • 85% of patients utilized left ventricular assist systems (LVAS) as a bridge to transplantation, averaging 780 days of support.

Purpose of the Study:

  • To analyze the outcomes of heart transplantation in Japan.
  • To evaluate the effectiveness of LVAS as a bridge to HTx.
  • To assess long-term survival rates in Japanese HTx recipients.

Main Methods:

  • Modified bicaval technique for cardiac preservation using Celsior solution.
  • Initial immunosuppression involved triple therapy: cyclosporine, mycophenolate mofetil, and steroids.

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  • Data collected up to September 2008, covering procedures since October 1997.

    • Main Results:

    • Achieved a 9-year survival rate of 94%.
    • This survival rate surpasses international registry benchmarks.
    • Excellent outcomes were observed despite donor shortages and long LVAS support durations.

    Conclusions:

    • Heart transplantation in Japan yields excellent results.
    • The use of LVAS is crucial for bridging patients to transplantation.
    • Despite donor scarcity, Japanese HTx program demonstrates high efficacy and survival.