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Biotechnology core laboratories: An overview.

D A McMillen¹, L Bibbs, N Denslow

¹Institute of Molecular Biology, University of Oregon, Eugene, OR 97403, USA. mcmillen@molbio.uoregon.edu

Journal of Biomolecular Techniques : JBT

|June 6, 2009

Summary

This summary is machine-generated.

Biotechnology core facilities offer essential services like protein and DNA sequencing. A survey revealed typical facilities have three staff, occupy 1100 sq ft, and provide services including MALDI mass spectrometry and bioinformatics support.

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Area of Science:

Biotechnology
Core Facilities
Research Infrastructure

Background:

Assessing biotechnology core facility capabilities requires data on technology, personnel, space, services, finances, and demand.
Such data is crucial for researchers, facility staff, administrators, and funding agencies.

Purpose of the Study:

To survey the operational and technical capabilities of core facilities.
To gather current data on state-of-the-art technologies and services offered.

Main Methods:

A general survey was conducted by the Association of Biomolecular Resource Facilities (ABRF).
81 ABRF core laboratories voluntarily responded, with 60% from academic institutions.
Financial data was provided by 50 laboratories, with 47 operating on a nonprofit basis.

Main Results:

Typical facilities have 3 full-time staff and occupy ~1100 sq ft.
Common services include N-terminal protein sequencing, peptide synthesis, DNA synthesis, and DNA sequencing.
Newer services like MALDI mass spectrometry and bioinformatics support are offered by one-third of facilities.

Conclusions:

Biotechnology core facilities are diverse in their services and operational models.
Emerging technologies such as MALDI mass spectrometry and bioinformatics are increasingly integrated.
Understanding facility resources is key for optimizing research support and strategic planning.