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Updated: Jun 22, 2026
14:57
Yeast As a Chassis for Developing Functional Assays to Study Human P53
Published on: August 4, 2019
Polymorphisms of TP53 codon 72 with prostate carcinoma risk: a meta-analysis
Jing Zhang1, Wen-Lei Zhuo, Ying Zheng
1Department of Nephrology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
Medical Oncology (Northwood, London, England)
|June 6, 2009
Summary
TP53 codon 72 polymorphisms are not definitively linked to prostate cancer overall. However, the Arg allele may increase risk in Caucasians, but not in Asians, suggesting a low-penetrant role.
Area of Science:
- Genetics
- Oncology
- Molecular Epidemiology
Background:
- TP53 codon 72 polymorphisms have been implicated as potential risk factors for various cancers.
- Previous studies on the association between TP53 codon 72 polymorphisms and prostate carcinoma susceptibility have produced conflicting results.
- A comprehensive meta-analysis is needed to clarify the relationship between TP53 codon 72 polymorphisms and prostate cancer risk.
Purpose of the Study:
- To conduct a systematic meta-analysis to determine the association between TP53 codon 72 polymorphisms and prostate carcinoma.
- To provide a more precise estimation of the relationship by pooling data from multiple case-control studies.
- To investigate potential ethnic differences in the association between TP53 codon 72 polymorphisms and prostate cancer.
Main Methods:
- A systematic literature search was performed across major databases (Medline, EMBASE, OVID, Sciencedirect, CNKI) up to February 2009.
- Six case-control studies, comprising 582 cases and 1075 controls, met the inclusion criteria.
- Data were extracted and analyzed using meta-analysis techniques, including subgroup analysis by ethnicity.
Main Results:
- Overall, no significant association was found between TP53 codon 72 polymorphisms and prostate carcinoma risk across different genetic models.
- Subgroup analysis indicated that individuals carrying the Arg allele might have an increased susceptibility to prostate cancer in Caucasians.
- In contrast, TP53 codon 72 polymorphism was unlikely to be a risk factor for prostate cancer in Asians, and showed minimal effect on metastasis or differentiation.
Conclusions:
- TP53 codon 72 polymorphism may act as a low-penetrant risk factor for prostate carcinoma in Caucasians.
- The association between TP53 codon 72 polymorphism and prostate cancer risk differs between Caucasian and Asian populations.
- TP53 codon 72 polymorphism appears to have a limited role in the metastasis and differentiation of prostate carcinoma.
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