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Mania associated with clonazepam.

A Dorevitch1

  • 1Faculty of Medicine, Hadassah Hebrew University, Jerusalem, Israel.

DICP : the Annals of Pharmacotherapy
|September 1, 1991
PubMed
Summary
This summary is machine-generated.

Clonazepam, a benzodiazepine, can induce manic symptoms in some patients with schizophrenia. Discontinuation and electroconvulsive therapy resolved the episode, highlighting potential risks.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Pharmacology

Background:

  • Clonazepam is a long-acting benzodiazepine used for seizures.
  • Initial studies suggested efficacy in treating acute mania with a good side-effect profile.

Observation:

  • A 41-year-old patient with chronic schizophrenia received adjunctive clonazepam.
  • At an 8-mg dosage, the patient developed manic symptoms including pressured speech, euphoria, and agitation.

Findings:

  • The patient experienced a manic episode while on clonazepam.
  • Electroconvulsive therapy combined with clonazepam tapering led to symptom resolution.

Implications:

  • Clonazepam may precipitate manic-like behavior in susceptible individuals, particularly those with schizophrenia.
  • Clinicians should monitor for manic symptoms when prescribing clonazepam to at-risk patients.