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Updated: Jun 22, 2026
08:49
A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
Primary dermal melanoma: A case report and molecular characterization
Yasutoshi Hida1, Yoshiaki Kubo, Osamu Miyajima
1Department of Dermatology, Institute of Health Biosciences, The University of Tokushima Graduate School, Japan.
The Journal of Dermatology
|June 9, 2009
Summary
Primary dermal melanoma (PDM) is a distinct entity with an excellent prognosis. This case highlights PDM
Area of Science:
- Dermatopathology
- Oncology
Background:
- Primary dermal melanoma (PDM) is recognized as a distinct entity with a favorable prognosis.
- Histopathological differentiation of PDM from metastatic melanoma and clear cell sarcoma (CCS) can be challenging due to overlapping features.
Observation:
- A case of a 38-year-old woman with a subcutaneous thigh tumor is presented.
- Initial examinations ruled out metastatic melanoma.
- Immunohistochemistry revealed strong KIT expression, but specific CCS fusion transcripts were absent.
Findings:
- KIT expression was observed in a significant proportion of primary and metastatic melanomas.
- KIT expression was notably absent in both primary and metastatic clear cell sarcoma.
- The presented case, exhibiting strong KIT expression without CCS markers, is consistent with PDM.
Implications:
- Emphasizes the diagnostic utility of KIT expression in distinguishing PDM.
- Reinforces the distinct clinicopathological identity of primary dermal melanoma.
- Aids in accurate diagnosis and appropriate patient management for PDM.
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