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Updated: Jun 22, 2026

An In Ovo Model for Testing Insulin-mimetic Compounds
Published on: April 23, 2018
[Diabetes in infants may be treated with sulfonylurea as a replacement for insulin]
Mette Høj Lauridsen1, Trine Welløv Boesgaard, Oluf Borbye Pedersen
1Regionshospitalet Viborg, Børneafdelingen. lauridsen.mette@gmail.com
Abstract:
A two-month-old Danish girl was admitted to the hospital in diabetic ketoacidosis and diagnosed with permanent neonatal diabetes mellitus (PNDM). She received continuous insulin treatment until she was genetically tested at the Steno Diabetes Centre. She carried a KCNJ11 Arg201His mutation, an activating mutation in the KCNJ11-gene which encodes the ATP-sensitive potassium subunit Kir6.2 in the beta cell which is responsible for insulin secretion. As recommended in the literature, she was successfully shifted from insulin therapy to sulfonylurea tablets at the age of three years and nine months. PNDM-patients should be screened for gene mutations regardless of current age.
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