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Updated: Jun 22, 2026

Diagnosis of Neoplasia in Barrett’s Esophagus using Vital-dye Enhanced Fluorescence Imaging
Published on: May 11, 2014
Histology of metaplasia and dysplasia in Barrett's esophagus
1Hepatobiliary and Gastrointestinal Pathology, Cleveland Clinic Lerner College of Medicine, Cleveland, OH, USA. yerianl@ccf.org
Abstract:
The histologic diagnosis of Barrett's dysplasia requires the identification of intestinal metaplasia, which often presents a challenge due to sampling error, observer variation, and difficulty in histologic interpretation. Particularly problematic is the separation of negative, indefinite, and low-grade dysplasia, the varied histological appearances of high-grade dysplasia, and the diagnosis of suboptimal biopsy material. This article seeks to aid in the histological evaluation of metaplasia and dysplasia in Barrett's esophagus.
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