Related Experiment Video
Updated: Sep 4, 2026

Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas
Published on: September 13, 2019
Rare Tumors: Part Two
Erica C Arnold1, Josélio Rodrigues de Oliveira Filho2, Danielle B Cameron2
1Center for Surgical Outcomes Research, Nationwide Children's Hospital, Columbus, OH, USA.
Abstract:
Adrenocortical carcinoma (ACC) and colorectal cancer (CRC) are rare tumors that can be seen in pediatric and adolescent patients. Both are associated with underlying cancer predisposition syndromes, most commonly Li-Fraumeni syndrome for ACC and familial adenomatous polyposis and Lynch syndrome for CRC. The mainstay of treatment for these diseases is surgical resection, with chemotherapy and other targeted therapies being used for advanced disease. Pediatric CRC and ACC have distinct molecular characteristics from those of their adult counterparts, and should be managed at specialized centers with a multidisciplinary approach to optimize outcomes.
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