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The level of malondialdehyde-modified LDL and LDL immune complexes in patients with rheumatoid arthritis

Junjun Wang1, Bing Hu, Yang Meng

  • 1Department of Biochemistry, Jinling Hospital, Clinical School of Medical College, Nanjing University, 305#, East Zhong Shan Road, Nanjing, 210002, PR China. wangjj6@jlonline.com

Clinical Biochemistry
|June 9, 2009
PubMed
Abstract

Insights

High levels of malondialdehyde-modified low-density lipoprotein (MDA-LDL) and LDL-immune complexes (LDL-IC) are linked to atherosclerosis in rheumatoid arthritis (RA) patients. These markers are associated with inflammation and indicate increased cardiovascular risk.

Area of Science:

  • Cardiovascular Research
  • Rheumatology
  • Biochemistry

Background:

  • Rheumatoid arthritis (RA) is associated with an increased risk of atherosclerosis.
  • The specific roles of modified lipoproteins in RA-related cardiovascular disease require further elucidation.

Purpose of the Study:

  • To investigate the association between malondialdehyde-modified low-density lipoprotein (MDA-LDL) and LDL-immune complexes (LDL-IC) with atherosclerosis in rheumatoid arthritis (RA) patients.

Main Methods:

  • Plasma levels of MDA-LDL and LDL-IC were measured in RA patients with or without coronary artery disease (CAD), patients with simple CAD, and healthy controls.
  • Statistical analyses, including multiple linear regression, were employed to identify factors influencing MDA-LDL and LDL-IC levels.

Main Results:

  • MDA-LDL and LDL-IC levels were elevated in all patient groups, with the highest levels observed in RA patients who also had CAD.
  • MDA-LDL levels were significantly higher in RA patients with CAD compared to those with RA alone or CAD alone.
  • CAD, LDL-IC, and erythrocyte sedimentation rate explained 36.5% of the variation in MDA-LDL levels. Age, disease activity, MDA-LDL, and rheumatoid factors explained 34.5% of the variation in LDL-IC.

Conclusions:

  • Elevated MDA-LDL and LDL-IC are significant risk factors for atherosclerosis in RA patients.
  • These modified lipoproteins are associated with inflammation, contributing to the heightened cardiovascular risk observed in RA.

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