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Related Experiment Video

Updated: Jun 22, 2026

4-Dimensional Imaging of Zebrafish Optic Cup Morphogenesis
07:26

4-Dimensional Imaging of Zebrafish Optic Cup Morphogenesis

Published on: May 26, 2021

ojoplano-mediated basal constriction is essential for optic cup morphogenesis.

Juan Ramon Martinez-Morales1, Martina Rembold, Klaus Greger

  • 1Developmental unit, EMBL, Meyerhofstrasse 1, 69117 Heidelberg, Germany. jrmarmor@upo.es

Development (Cambridge, England)
|June 9, 2009
PubMed
Summary

The ojoplano (opo) gene is crucial for optic cup folding during eye development. Opo protein regulates cell adhesion, ensuring proper mechanical tension for vertebrate eye shape formation.

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Area of Science:

  • Developmental biology
  • Cell biology
  • Ophthalmology

Background:

  • Vertebrate retina development is a key model for organogenesis.
  • Mechanisms of optic cup morphogenesis are not fully understood.
  • Cellular coordination drives epithelial morphogenesis.

Purpose of the Study:

  • Investigate the role of ojoplano (opo) in epithelial morphogenesis.
  • Determine how opo mutations affect optic cup folding in medaka fish.
  • Elucidate the cellular mechanisms underlying opo-dependent eye development.

Main Methods:

  • In vivo characterization of optic cup morphogenesis in medaka fish.
  • Analysis of ojoplano (opo) gene function and protein localization.
  • Investigating the role of Opo in focal adhesion and integrin function.

Main Results:

  • Opo is a transmembrane protein localized to the secretory pathway and basal cell surfaces.
  • Opo mutations impair optic cup folding, affecting eye shape.
  • Opo regulates polarized localization of focal adhesion components.
  • Interference with integrin function mimics opo mutant ocular phenotype.

Conclusions:

  • Opo-mediated focal contact formation is essential for transmitting mechanical tensions.
  • These tensions drive the macroscopic folding of the vertebrate optic cup.
  • Opo plays a critical role in the morphogenesis of the vertebrate eye.