Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genetic Screens02:46

Genetic Screens

5.8K
Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
5.8K
Gene-Environment Interactions01:20

Gene-Environment Interactions

1.3K
Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
1.3K
Epistasis Analysis01:09

Epistasis Analysis

6.0K
Although Mendel chose seven unrelated traits in peas to study gene segregation, most traits involve multiple gene interactions that create a spectrum of phenotypes. When the interaction of various genes or alleles at different locations influences a phenotype, this is called epistasis. Epistasis often involves one gene masking or interfering with the expression of another (antagonistic epistasis). Epistasis often occurs when different genes are part of the same biochemical pathway. The...
6.0K
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

6.6K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
6.6K
Background and Environment Affect Phenotype02:27

Background and Environment Affect Phenotype

7.9K
Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
7.9K
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

37.7K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
37.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multi-omic analysis of deep learning-derived phenotypes links ophthalmic imaging to cardiovascular and neurological traits.

Nature cardiovascular research·2026
Same author

A panel of medaka isogenic lines suggests individual, seasonal, and sexual genetic variation of <i>bdnf</i> gene expression in the brain.

Frontiers in behavioral neuroscience·2026
Same author

The Human Pleiotropic Map of GWAS Associations and Therapeutic Implications.

bioRxiv : the preprint server for biology·2026
Same author

Extrinsic polarity cues control lamination versus cluster-based organization in vertebrate retinal development.

iScience·2026
Same author

Hepatitis E virus replication is maintained in proliferative cells within the intestinal crypt.

Science advances·2026
Same author

Discovery and characterization of gene-by-environment and epistatic genetic effects in a vertebrate model.

Cell genomics·2026

Related Experiment Video

Updated: Feb 26, 2026

Microinjection of Medaka Embryos for use as a Model Genetic Organism
07:25

Microinjection of Medaka Embryos for use as a Model Genetic Organism

Published on: December 22, 2010

26.5K

Medaka: a novel model for analyzing genome-environment interactions.

Kiyoshi Naruse1, Felix Loosli2, Satoshi Ansai3

  • 1Laboratory of Bioresources, National Institute for Basic Biology, Okazaki 444-8585, Japan.

Trends in Genetics : TIG
|February 24, 2026
PubMed
Summary
This summary is machine-generated.

Medaka fish are a versatile vertebrate model for research, ideal for studying how genes and environment interact. Their adaptability and genetic resources support advanced studies in evolution and biomedicine.

Keywords:
GWASQTL mappinggenome–environment interactionsmedakapopulation genetics resourcewild-derived strains

More Related Videos

In Vivo Modeling of the Morbid Human Genome using Danio rerio
12:31

In Vivo Modeling of the Morbid Human Genome using Danio rerio

Published on: August 24, 2013

21.4K
Dechorionation of Medaka Embryos and Cell Transplantation for the Generation of Chimeras
09:03

Dechorionation of Medaka Embryos and Cell Transplantation for the Generation of Chimeras

Published on: December 22, 2010

18.4K

Related Experiment Videos

Last Updated: Feb 26, 2026

Microinjection of Medaka Embryos for use as a Model Genetic Organism
07:25

Microinjection of Medaka Embryos for use as a Model Genetic Organism

Published on: December 22, 2010

26.5K
In Vivo Modeling of the Morbid Human Genome using Danio rerio
12:31

In Vivo Modeling of the Morbid Human Genome using Danio rerio

Published on: August 24, 2013

21.4K
Dechorionation of Medaka Embryos and Cell Transplantation for the Generation of Chimeras
09:03

Dechorionation of Medaka Embryos and Cell Transplantation for the Generation of Chimeras

Published on: December 22, 2010

18.4K

Area of Science:

  • * Vertebrate model systems
  • * Genomics and epigenetics
  • * Evolutionary biology

Background:

  • * Medaka (fish) is a well-established model for biological and biomedical research.
  • * Possesses unique ecological adaptability (4-40°C, varying salinities) and experimental tractability.
  • * High tolerance to inbreeding allows for creation of genetically uniform research panels.

Purpose of the Study:

  • * To highlight medaka's suitability for studying genome-environment interactions.
  • * To showcase the utility of diverse medaka strains and advanced genetic tools.
  • * To position medaka as a framework for integrating genetic, environmental, and epigenetic research.

Main Methods:

  • * Utilization of the Medaka Inbred Kiyosu-Karlsruhe panel (80 near-isogenic lines).
  • * Analysis of over 100 wild-derived, fully sequenced medaka strains.
  • * Application of advanced quantification methods for genome-wide association studies (GWAS) and quantitative trait locus (QTL) mapping.
  • * Employing clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 gene editing and epigenomic profiling.

Main Results:

  • * Medaka exhibits low intra-strain variation but high inter-strain variability (SNP rates >4%).
  • * The system supports advanced genetic analyses like GWAS and QTL mapping.
  • * CRISPR/Cas9 editing and epigenomic profiling facilitate causal validation and discovery of regulatory mechanisms.

Conclusions:

  • * Medaka provides an unparalleled vertebrate framework for integrating genetics, environment, and epigenetics.
  • * This model system bridges evolutionary, biomedical, and population-level research perspectives.
  • * Its unique features enable comprehensive studies of complex biological interactions.