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Updated: Jun 22, 2026

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method
Published on: October 7, 2025
(micro)Genomic medicine: microRNAs as therapeutics and biomarkers
Matthew A Saunders1, Lee P Lim
1Sirna Therapeutics, a Wholly Owned Subsidiary of Merck & Co, San Francisco, CA 94158, USA.
Abstract:
Genomic studies have shown that a microRNA(miRNA) can post-transcriptionally regulate hundreds of other genes, providing challenges and opportunities for therapeutic development. Profiling studies have placed several miRNAs within transcriptional pathways linked to disease, and oligonucleotide therapeutics are being developed that modulate miRNA activity. The involvement of miRNAs in diverse genetic pathways across human tissues suggests that miRNAs will also be useful as biomarkers for disease and tissue injury.
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