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A Morphometric and Cellular Analysis Method for the Murine Mandibular Condyle

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Mandible shape in hybrid mice.

Sabrina Renaud¹, Paul Alibert, Jean-Christophe Auffray

¹Paléoenvironnement et Paléobiosphère, UMR 5125 CNRS, Université Lyon 1, Bâtiment Géode, 2 Rue Dubois, Campus de la Doua, 69622 Villeurbanne Cedex, France. Sabrina.Renaud@univ-lyon1.fr

Die Naturwissenschaften

|June 9, 2009

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Hybridization between mouse subspecies can create novel phenotypes and increase genetic variance. This evolutionary process may lead to new, transgressive traits by combining parental genomes.

Area of Science:

Evolutionary biology
Developmental biology
Genetics

Background:

Hybridization between closely related species can influence evolutionary divergence.
Novel phenotypes can arise from new genetic combinations and developmental interactions during hybridization.
Mandible shape in mice is a studied feature in evolutionary and developmental (evo-devo) research.

Purpose of the Study:

To investigate the effects of hybridization on the shape of the mouse mandible.
To understand how hybridization impacts phenotypic variance and evolutionary divergence in Mus musculus subspecies.

Main Methods:

Controlled breeding of parental mouse strains (Mus musculus domesticus and Mus musculus musculus) and their F(1) hybrids.
Analysis of mandible shape in parent and hybrid groups.

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Assessment of phenotypic variance and transgressive effects in hybrids.

Main Results:

F(1) mouse hybrids exhibited mandible shapes that were largely intermediate between parental phenotypes.
A transgressive effect and increased phenotypic variance were observed in the hybrids.
Hybridization led to higher phenotypic variance due to complex parental genome interactions, including non-additive genetic effects.

Conclusions:

Hybridization between Mus musculus subspecies can increase phenotypic variance and produce novel transgressive phenotypes.
This process, driven by complex genetic interactions, may play a role in generating evolutionary novelty.
While variance increases, the major direction of variance is conserved across parent and hybrid groups.